Matches in SemOpenAlex for { <https://semopenalex.org/work/W107254005> ?p ?o ?g. }
- W107254005 endingPage "193" @default.
- W107254005 startingPage "175" @default.
- W107254005 abstract "There is increasing evidence that almost all idiosyncratic drug-induced liver injury (IDILI) is mediated by the adaptive immune system. The incidence of mild injury that resolves despite continued treatment is much higher than that of liver failure. This response is referred to as adaptation, but if the injury is immune-mediated, then adaptation presumably represents immune tolerance, which is the dominant immune response in the liver. One mechanism for immune tolerance in the liver appears to involve direct activation of CD8+ T cells by hepatocytes, leading to their death. T regulatory cells and M2 macrophages also contribute to immune tolerance. Different patients can have different idiosyncratic reactions to the same drug, which is probably caused by differences in their HLA and T cell receptor repertoire. A better understanding of the mechanisms of IDILI would likely make it easier to predict which drug candidates are likely to cause such reactions and to develop better ways of treating them." @default.
- W107254005 created "2016-06-24" @default.
- W107254005 creator A5039008828 @default.
- W107254005 date "2013-01-01" @default.
- W107254005 modified "2023-09-23" @default.
- W107254005 title "Role of the Adaptive Immune System in Idiosyncratic Drug-Induced Liver Injury" @default.
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