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- W107497867 abstract "Publisher SummaryThis chapter reviews the assays for lymphokines supporting B cell growth. It has been shown that activated B cells respond to soluble molecules in supernatants from in vitro–propagated helper T-cell cultures or to supernatants from Con A–activated rat spleen cells, with increased thymidine uptake and maturation to plaque-forming cells. Subsequently, lymphokines selectively supporting growth of activated B cell populations have been reported, and a variety of activities inducing maturation to immunoglobulin (Ig) secretion have been described. Some of the problems associated with analysis of factor-mediated B cell growth and maturation are worth noting. Most assays for lymphokines measure in vitro phenomena in complex mixtures of cells. As a consequence, it is unclear whether activities function directly or indirectly on B cells. This problem is obviated using cloned tumor cells as responders in growth and differentiation assays. Additional complications arise because of the heterogeneity of factor-containing supernatants. It is hard to determine whether an in vitro effect is because of one class of molecules or several. Also becoming problematic is the fact that many lymphokines tend to copurify on most conventional columns. Attempts to purify cell populations, alter cell densities, and reduce serum concentrations in culture media might create artificial in vitro requirements that are merely necessary for life maintenance in general and not specifically related to growth and differentiation." @default.
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- W107497867 date "1985-01-01" @default.
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- W107497867 title "Assays for Lymphokines Supporting B Cell Growth" @default.
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- W107497867 doi "https://doi.org/10.1016/b978-0-12-442703-7.50019-x" @default.
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