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- W107512581 abstract "To test the potential of Quantitative Tissue Phenotype (QTP) analysis to discriminate (1) margins with different grades of dysplasia (2) margins with or without tissue autofluoresecnece change; (3) and patients who reached primary end point or local recurrence from those who did not. Surgery samples were collected from a prospective multi-centre phase III randomized controlled trial of a total of 400 patients to either Fluorescence Visualization (FV)-guided or non-FV-guided surgical intervention. Margins with or without FV alterations were collected from anterior, posterior, medial, and lateral margins of the specimen are subject for t pathology assessment and QTP analysis. Based on an independent training set of 32 oral lesions with known outcome of progression, the threshold value of the QTP score was set to 0.57; margins with scores below 0.57 were considered low-risk and those whose scores above 0.57 were considered high-risk. A total of 302 margins from 66 patients with at least 6 months follow-up were analyzed by QTP. Among them, 169 of the 252 hyperplasia (67%) were high-risk, 16 of the 27 mild dysplasia (59%) were high-risk, 16 of the 21 moderate (76%) were high-risk, and both severe dysplasias (100%) were high-risk. Twenty-one of the 28 FVpos margins (75%) were high-risk whereas 181 of the 274 FVneg margins (66%) were high-risk. Finally, among the 13 dysplasias with follow-up, 63% of the 8 cases with no sign of dysplasia were high-risk, whereas 80% of the 5 cases showing dysplastic changes were high-risk. This preliminary QTP analysis shows positive correlation with margin evaluation and supports the removal of surgical field as revealed by fluorescence visualization. the COOLS trial will gather more definitive evidence to use QP as a surrogate to predict recurrence as well as determine the benefit and risk of altering surgical margin delineation. (Supported by TFRI 2009–2024)" @default.
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- W107512581 date "2013-05-01" @default.
- W107512581 modified "2023-10-18" @default.
- W107512581 title "OP022" @default.
- W107512581 doi "https://doi.org/10.1016/j.oraloncology.2013.03.030" @default.
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