Matches in SemOpenAlex for { <https://semopenalex.org/work/W1075423> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1075423 endingPage "418" @default.
- W1075423 startingPage "413" @default.
- W1075423 abstract "Luteinizing-hormone-stimulated testosterone biosynthesis was inhibited by cycloheximide during incubation of rat testis intersitial tissue in vitro and also by puromycin and cycloheximide during incubation of Leydig-cell preparations, but not by chloramphenicol. These results suggest that a protein regualtor(s) formed by cytoplasmic protein synthesis is involved in steroidogenesis in the rat testis. The specific effect of cycloheximide and puromycin on protein synthesis rather than on other non-specific processes is suggested by the inhibition of protein synthesis and steroidogenesis with different doses of the inhibitors and the lack of effect of cycloheximide on luteinizing-hormone-induced adenosine 3′:5′-cyclic monophosphate production. Stimulation of testosterone production by luteinizing hormone during superfusion of interstitial tissue was detectable within 10-20 min and reached a maximum of 120 min, and thereafter slowly decreased. Cycloheximide added at maximum steroid production caused a rapid decrease in testosterone synthesis which followed first-order kinetics (half-life 13 min), thus indicating that the protein regulator(s) has a short half-life. No effect of cycloheximide, puromycin or chloramphenicol on testosterone production in the absence of added luteinizing hormone was found, suggesting that the basal production of testosterone is independent of protein synthesis." @default.
- W1075423 created "2016-06-24" @default.
- W1075423 creator A5012764347 @default.
- W1075423 creator A5017072016 @default.
- W1075423 creator A5028874196 @default.
- W1075423 creator A5086937911 @default.
- W1075423 date "1975-09-01" @default.
- W1075423 modified "2023-09-26" @default.
- W1075423 title "Effect of protein-synthesis inhibitors on testosterone production in rat testis interstitial tissue and Leydig-cell preparations" @default.
- W1075423 cites W1521882551 @default.
- W1075423 cites W1532140047 @default.
- W1075423 cites W1583788306 @default.
- W1075423 cites W1775749144 @default.
- W1075423 cites W1963598422 @default.
- W1075423 cites W1964423926 @default.
- W1075423 cites W1967799268 @default.
- W1075423 cites W1982425063 @default.
- W1075423 cites W2004994757 @default.
- W1075423 cites W2021461380 @default.
- W1075423 cites W2039803215 @default.
- W1075423 cites W2040028421 @default.
- W1075423 cites W2041903250 @default.
- W1075423 cites W2046728975 @default.
- W1075423 cites W2076384435 @default.
- W1075423 cites W2081487791 @default.
- W1075423 cites W2086463293 @default.
- W1075423 cites W2088025053 @default.
- W1075423 cites W2103684647 @default.
- W1075423 cites W2132966886 @default.
- W1075423 cites W25047711 @default.
- W1075423 cites W30517551 @default.
- W1075423 doi "https://doi.org/10.1042/bj1500413" @default.
- W1075423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1165756" @default.
- W1075423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/174545" @default.
- W1075423 hasPublicationYear "1975" @default.
- W1075423 type Work @default.
- W1075423 sameAs 1075423 @default.
- W1075423 citedByCount "97" @default.
- W1075423 countsByYear W10754232013 @default.
- W1075423 countsByYear W10754232014 @default.
- W1075423 countsByYear W10754232018 @default.
- W1075423 countsByYear W10754232021 @default.
- W1075423 crossrefType "journal-article" @default.
- W1075423 hasAuthorship W1075423A5012764347 @default.
- W1075423 hasAuthorship W1075423A5017072016 @default.
- W1075423 hasAuthorship W1075423A5028874196 @default.
- W1075423 hasAuthorship W1075423A5086937911 @default.
- W1075423 hasBestOaLocation W10754232 @default.
- W1075423 hasConcept C126322002 @default.
- W1075423 hasConcept C134018914 @default.
- W1075423 hasConcept C2777534427 @default.
- W1075423 hasConcept C2777736315 @default.
- W1075423 hasConcept C2778128677 @default.
- W1075423 hasConcept C2778575703 @default.
- W1075423 hasConcept C2779200571 @default.
- W1075423 hasConcept C2779279991 @default.
- W1075423 hasConcept C2781363766 @default.
- W1075423 hasConcept C3675279 @default.
- W1075423 hasConcept C55493867 @default.
- W1075423 hasConcept C71315377 @default.
- W1075423 hasConcept C71924100 @default.
- W1075423 hasConcept C86803240 @default.
- W1075423 hasConceptScore W1075423C126322002 @default.
- W1075423 hasConceptScore W1075423C134018914 @default.
- W1075423 hasConceptScore W1075423C2777534427 @default.
- W1075423 hasConceptScore W1075423C2777736315 @default.
- W1075423 hasConceptScore W1075423C2778128677 @default.
- W1075423 hasConceptScore W1075423C2778575703 @default.
- W1075423 hasConceptScore W1075423C2779200571 @default.
- W1075423 hasConceptScore W1075423C2779279991 @default.
- W1075423 hasConceptScore W1075423C2781363766 @default.
- W1075423 hasConceptScore W1075423C3675279 @default.
- W1075423 hasConceptScore W1075423C55493867 @default.
- W1075423 hasConceptScore W1075423C71315377 @default.
- W1075423 hasConceptScore W1075423C71924100 @default.
- W1075423 hasConceptScore W1075423C86803240 @default.
- W1075423 hasIssue "3" @default.
- W1075423 hasLocation W10754231 @default.
- W1075423 hasLocation W10754232 @default.
- W1075423 hasLocation W10754233 @default.
- W1075423 hasLocation W10754234 @default.
- W1075423 hasOpenAccess W1075423 @default.
- W1075423 hasPrimaryLocation W10754231 @default.
- W1075423 hasRelatedWork W1075423 @default.
- W1075423 hasRelatedWork W1966746704 @default.
- W1075423 hasRelatedWork W1988486434 @default.
- W1075423 hasRelatedWork W2012502375 @default.
- W1075423 hasRelatedWork W2047880909 @default.
- W1075423 hasRelatedWork W2057000165 @default.
- W1075423 hasRelatedWork W2086384643 @default.
- W1075423 hasRelatedWork W2163989763 @default.
- W1075423 hasRelatedWork W2313856518 @default.
- W1075423 hasRelatedWork W4244220854 @default.
- W1075423 hasVolume "150" @default.
- W1075423 isParatext "false" @default.
- W1075423 isRetracted "false" @default.
- W1075423 magId "1075423" @default.
- W1075423 workType "article" @default.