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- W107591750 abstract "Background: c-myb encodes the transcription factor c-Myb, which is involved in hematopoiesis (HP) and vascular smooth muscle cell (SMC) proliferation. However, a mechanism for why c-myb knockout (KO) mouse embryonic stem cells (ESC) cannot form contractile SMC in embryoid bodies (EB), but form contracting cardiomyocytes (CM) with greater efficiency than wild-type (WT) ESC, was not known. Flk1 and PDGFRα are surface markers used to identify early progenitors. Here we report on the regulated expression and role of c-Myb during SMC differentiation from specific progenitors. Methods & Results: Western blot revealed high levels of c-Myb on d0-2 of differentiation in WT EB, with rapid and complete loss of c-Myb on d2.5-3, and re-expression on d4−6. Loss of c-Myb on d2.5-3 was not associated with changes in c-myb mRNA, but was completely blocked by the proteosome inhibitor MG132. ESC-derived cardiovascular progenitors induced by Activin-A and BMP4 underwent flow cytometry for Flk1 and PDGFRα. By d3.75, the appea..." @default.
- W107591750 created "2016-06-24" @default.
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- W107591750 date "2010-11-23" @default.
- W107591750 modified "2023-09-27" @default.
- W107591750 title "Abstract 16067: c-Myb Levels Regulate Flk1+ Progenitors and Subsequent Smooth Muscle Differentiation From Mouse Embryonic Stem Cells." @default.
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