FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W107693689> ?p ?o ?g. }

• W107693689 endingPage "146" @default.
• W107693689 startingPage "139" @default.
• W107693689 abstract "The stage and tissue specific expression of milk protein genes in the mammary gland is controlled by modular response regions with multiple binding sites for distinct classes of transcription factors, which either co-operate or are antagonistic. In addition, the activity of some of these factors is individually control-led by diverse extracellular signals. A well studied paradigm for a synergistic co-operation is the activation of beta-casein gene transcription by prolactin and glucocorticoids mediated by the signal transducer and activator of transcription STAT5 and the glucocorticoid receptor (GR). As an example for an antagonistic interaction we can demonstrate inhibition of prolactin signalling by TNF-alpha, which is mediated by NF-kappa B. In both cases, the interactions occur at several levels: For GR and STAT5, the synergy is discussed to be promoted by protein-protein interactions. Furthermore, we can demonstrate a co-operation between GR and STAT5 in DNA binding by a mechanism, which is dependent on the integrity of the DNA binding domain of the GR and on the existence of half-palindromic GR binding sites in the hormone response region. Indirect effects of glucocorticoids by modulation of the expression of secondary genes are also important. They might account for the observed enhancement of prolactin induced tyrosine phosphorylation of STAT5 by glucocorticoids. For NF-kappa B and STAT5, one component of the antagonism is the inhibition of STAT5 tyrosine phosphorylation by activation of NF-kappa B. Another potential mechanism is the inhibition of DNA binding of STAT5 due to overlapping binding sites for STAT5 and NF-kappa B in the beta-casein gene promoter. Thus, synergistic and antagonistic interactions between GR, NF-kappa B, and STAT5 involve (a) cross-talk mechanisms influencing the activation of STAT5 and (b) promoter-dependent interactions modulating the DNA binding activity of the transcription factors." @default.
• W107693689 created "2016-06-24" @default.
• W107693689 creator A5040300044 @default.
• W107693689 creator A5043391310 @default.
• W107693689 creator A5081681805 @default.
• W107693689 date "2005-11-21" @default.
• W107693689 modified "2023-10-14" @default.
• W107693689 title "Synergistic and Antagonistic Interactions of Transcription Factors in the Regulation of Milk Protein Gene Expression" @default.
• W107693689 cites W1544289096 @default.
• W107693689 cites W1775297890 @default.
• W107693689 cites W1801713977 @default.
• W107693689 cites W1837711156 @default.
• W107693689 cites W1854096392 @default.
• W107693689 cites W1882868104 @default.
• W107693689 cites W1970637755 @default.
• W107693689 cites W1977176665 @default.
• W107693689 cites W1993333697 @default.
• W107693689 cites W2003523045 @default.
• W107693689 cites W2019284238 @default.
• W107693689 cites W2023684484 @default.
• W107693689 cites W2030928449 @default.
• W107693689 cites W2039057191 @default.
• W107693689 cites W2040495689 @default.
• W107693689 cites W2059460020 @default.
• W107693689 cites W2062439727 @default.
• W107693689 cites W2079331878 @default.
• W107693689 cites W2080539159 @default.
• W107693689 cites W2110634031 @default.
• W107693689 cites W2111603047 @default.
• W107693689 cites W2115743660 @default.
• W107693689 cites W2120464397 @default.
• W107693689 cites W2135126479 @default.
• W107693689 cites W2156660300 @default.
• W107693689 cites W2167517334 @default.
• W107693689 cites W2339236927 @default.
• W107693689 cites W4238213193 @default.
• W107693689 cites W4240274314 @default.
• W107693689 cites W4242425751 @default.
• W107693689 cites W4242577302 @default.
• W107693689 cites W4242665862 @default.
• W107693689 cites W4255885398 @default.
• W107693689 cites W4553897 @default.
• W107693689 doi "https://doi.org/10.1007/0-306-46832-8_17" @default.
• W107693689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10959420" @default.
• W107693689 hasPublicationYear "2005" @default.
• W107693689 type Work @default.
• W107693689 sameAs 107693689 @default.
• W107693689 citedByCount "22" @default.
• W107693689 countsByYear W1076936892012 @default.
• W107693689 countsByYear W1076936892014 @default.
• W107693689 countsByYear W1076936892016 @default.
• W107693689 countsByYear W1076936892019 @default.
• W107693689 countsByYear W1076936892023 @default.
• W107693689 crossrefType "book-chapter" @default.
• W107693689 hasAuthorship W107693689A5040300044 @default.
• W107693689 hasAuthorship W107693689A5043391310 @default.
• W107693689 hasAuthorship W107693689A5081681805 @default.
• W107693689 hasConcept C101762097 @default.
• W107693689 hasConcept C104317684 @default.
• W107693689 hasConcept C11960822 @default.
• W107693689 hasConcept C132376346 @default.
• W107693689 hasConcept C138885662 @default.
• W107693689 hasConcept C150194340 @default.
• W107693689 hasConcept C153911025 @default.
• W107693689 hasConcept C171958077 @default.
• W107693689 hasConcept C179926584 @default.
• W107693689 hasConcept C185592680 @default.
• W107693689 hasConcept C2777553839 @default.
• W107693689 hasConcept C2778923194 @default.
• W107693689 hasConcept C2779064019 @default.
• W107693689 hasConcept C2779391668 @default.
• W107693689 hasConcept C2781031661 @default.
• W107693689 hasConcept C41895202 @default.
• W107693689 hasConcept C55493867 @default.
• W107693689 hasConcept C59493245 @default.
• W107693689 hasConcept C71315377 @default.
• W107693689 hasConcept C86339819 @default.
• W107693689 hasConcept C86803240 @default.
• W107693689 hasConcept C88045685 @default.
• W107693689 hasConcept C95444343 @default.
• W107693689 hasConceptScore W107693689C101762097 @default.
• W107693689 hasConceptScore W107693689C104317684 @default.
• W107693689 hasConceptScore W107693689C11960822 @default.
• W107693689 hasConceptScore W107693689C132376346 @default.
• W107693689 hasConceptScore W107693689C138885662 @default.
• W107693689 hasConceptScore W107693689C150194340 @default.
• W107693689 hasConceptScore W107693689C153911025 @default.
• W107693689 hasConceptScore W107693689C171958077 @default.
• W107693689 hasConceptScore W107693689C179926584 @default.
• W107693689 hasConceptScore W107693689C185592680 @default.
• W107693689 hasConceptScore W107693689C2777553839 @default.
• W107693689 hasConceptScore W107693689C2778923194 @default.
• W107693689 hasConceptScore W107693689C2779064019 @default.
• W107693689 hasConceptScore W107693689C2779391668 @default.
• W107693689 hasConceptScore W107693689C2781031661 @default.
• W107693689 hasConceptScore W107693689C41895202 @default.
• W107693689 hasConceptScore W107693689C55493867 @default.
• W107693689 hasConceptScore W107693689C59493245 @default.

• next