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• W107747243 abstract "Abstract The ability of cells derived from the K562 cell line to generate erythropoietic colonies was studied. The K562 cell line was derived from a patient with chronic myelogenous leukemia 8 yr ago by Lozzio and Lozzio. Rare benzidine-positive colonies formed when these cells were cloned in plasma clots (3 +/- 1/10(4) cells), and their number was not substantially increased by the addition of erythropoietin (9.5 +/- 1/10(4) cells). Sodium butyrate was capable of markedly enhancing the number of benzidine-positive colonies (19.5 +/- 1/10(4) cells) formed, while the combination of sodium butyrate plus erythropoietin exerted a synergistic effect on erythropoietic colony formation (57 +/- 4/10(4) cells). The K562 cell line is a long-term culture system that contains human erythropoietic stem cells. This cell line should be useful in future studies on the cellular and molecular events associated with human erythroid cell differentiation." @default.
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• W107747243 date "1979-11-01" @default.
• W107747243 modified "2023-10-16" @default.
• W107747243 title "Induction of erythropoietic colonies in a human chronic myelogenous leukemia cell line" @default.
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• W107747243 doi "https://doi.org/10.1182/blood.v54.5.1182.1182" @default.
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