Matches in SemOpenAlex for { <https://semopenalex.org/work/W107843540> ?p ?o ?g. }
- W107843540 endingPage "153" @default.
- W107843540 startingPage "133" @default.
- W107843540 abstract "Heavy alcohol consumption increases the incidence and severity of bacterial pneumonia and other infections. Neutrophil recruitment into the lung is a critical early host response to infection. This chapter focuses on the defects in neutrophil function and production in the alcohol-abusing host. Most of the preclinical literature on this subject has been produced using acute, intoxicating doses of alcohol. These models identify that alcohol-induced suppression of neutrophil recruitment and production are strongly associated with an increased severity of lung infection. Mechanisms responsible for this alcohol-induced granulocyte suppression include decreasing pro-inflammatory cytokine, CXC chemokine, and granulopoietic growth factor production. Neutrophil and/or granulocyte progenitor cell responsiveness to these mediators is also suppressed by alcohol. Additionally, studies indicate that neutrophil functions such as phagocytosis and pathogen killing may also be impaired by severe alcohol intoxication or chronic consumption. Human studies, though fewer in number, identify similar defects imparted by intoxicating concentrations of alcohol. Taken together, present knowledge supports the conclusion that defects in neutrophil recruitment, function and production are pivotal consequences of alcohol abuse and render the host susceptible to a multitude of respiratory infections." @default.
- W107843540 created "2016-06-24" @default.
- W107843540 creator A5015282403 @default.
- W107843540 creator A5015724183 @default.
- W107843540 creator A5086871896 @default.
- W107843540 date "2013-09-27" @default.
- W107843540 modified "2023-09-23" @default.
- W107843540 title "Alcohol Impairment of Granulocyte Function During Lung Infection" @default.
- W107843540 cites W1487235492 @default.
- W107843540 cites W1598923830 @default.
- W107843540 cites W1629188285 @default.
- W107843540 cites W1817249348 @default.
- W107843540 cites W1915525119 @default.
- W107843540 cites W1966264947 @default.
- W107843540 cites W1974458512 @default.
- W107843540 cites W1980772640 @default.
- W107843540 cites W1985134279 @default.
- W107843540 cites W1986394878 @default.
- W107843540 cites W198853106 @default.
- W107843540 cites W1991336686 @default.
- W107843540 cites W1992242528 @default.
- W107843540 cites W1995475766 @default.
- W107843540 cites W1996840207 @default.
- W107843540 cites W2000729312 @default.
- W107843540 cites W2000835105 @default.
- W107843540 cites W2002602416 @default.
- W107843540 cites W2012114706 @default.
- W107843540 cites W2015577242 @default.
- W107843540 cites W2015585437 @default.
- W107843540 cites W2019672305 @default.
- W107843540 cites W2020824798 @default.
- W107843540 cites W2021162850 @default.
- W107843540 cites W2023758601 @default.
- W107843540 cites W2024893274 @default.
- W107843540 cites W2027706002 @default.
- W107843540 cites W2030574089 @default.
- W107843540 cites W2032782593 @default.
- W107843540 cites W2033060813 @default.
- W107843540 cites W2038796948 @default.
- W107843540 cites W2041693925 @default.
- W107843540 cites W2041778320 @default.
- W107843540 cites W2047148239 @default.
- W107843540 cites W2054268009 @default.
- W107843540 cites W2054564332 @default.
- W107843540 cites W2056112680 @default.
- W107843540 cites W2059287796 @default.
- W107843540 cites W2059289753 @default.
- W107843540 cites W2059365438 @default.
- W107843540 cites W2061341693 @default.
- W107843540 cites W2068805684 @default.
- W107843540 cites W2071295383 @default.
- W107843540 cites W2077086034 @default.
- W107843540 cites W2080311121 @default.
- W107843540 cites W2084666176 @default.
- W107843540 cites W2085523579 @default.
- W107843540 cites W2092877182 @default.
- W107843540 cites W2092897179 @default.
- W107843540 cites W2094033013 @default.
- W107843540 cites W2101299878 @default.
- W107843540 cites W2101366590 @default.
- W107843540 cites W2104934425 @default.
- W107843540 cites W2106398910 @default.
- W107843540 cites W2106413142 @default.
- W107843540 cites W2108195875 @default.
- W107843540 cites W2108585076 @default.
- W107843540 cites W2111421688 @default.
- W107843540 cites W2113020218 @default.
- W107843540 cites W2114249751 @default.
- W107843540 cites W2118217258 @default.
- W107843540 cites W2118480748 @default.
- W107843540 cites W2119229144 @default.
- W107843540 cites W2120995443 @default.
- W107843540 cites W2124102408 @default.
- W107843540 cites W2125793559 @default.
- W107843540 cites W2127865041 @default.
- W107843540 cites W2130117150 @default.
- W107843540 cites W2135728875 @default.
- W107843540 cites W2136243103 @default.
- W107843540 cites W2138623142 @default.
- W107843540 cites W2141086773 @default.
- W107843540 cites W2141186997 @default.
- W107843540 cites W2142957108 @default.
- W107843540 cites W2145019007 @default.
- W107843540 cites W2147657681 @default.
- W107843540 cites W2150631988 @default.
- W107843540 cites W2152434300 @default.
- W107843540 cites W2157568924 @default.
- W107843540 cites W2157673587 @default.
- W107843540 cites W2158580948 @default.
- W107843540 cites W2158854771 @default.
- W107843540 cites W2160368373 @default.
- W107843540 cites W2160883911 @default.
- W107843540 cites W2165133447 @default.
- W107843540 cites W2170237721 @default.
- W107843540 cites W2170485407 @default.
- W107843540 cites W2239119657 @default.
- W107843540 cites W2326243556 @default.
- W107843540 cites W2330509630 @default.