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- W107913257 abstract "Anaesthesiologists have a special interest in pharmacology, maybe even more than other physicians who prescribe drugs and often follow narrow approved dosing guidelines. Anaesthetic drugs can be administered in a wide dose range, with relative under dosage (awareness, muscle tension or pain) adequate dosage and relative over dosage (late recovery, side effects) all being observed within the approved dose range. The art, or the science, of the anaesthetist is to choose both the drug and the dose in order to achieve an adequate level of anaesthesia as fast as possible and maintain it just as long as necessary in any individual patient. Pharmacokinetic and pharmacodynamic modelling helps to achieve these clinical goals by differentiation within the dose-effect relationship into a dose-concentration relationship and a concentration-effect relationship. Clinically, kinetic-dynamic modelling can be used to adjust the dose to a desired level of effect at any time through target-controlled delivery systems." @default.
- W107913257 created "2016-06-24" @default.
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- W107913257 date "2003-01-01" @default.
- W107913257 modified "2023-09-25" @default.
- W107913257 title "Clinical Application of Pharmacokinetic and Pharmacodynamic Models" @default.
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- W107913257 doi "https://doi.org/10.1007/978-1-4419-9192-8_6" @default.
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