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- W108014107 abstract "Thirteen years have passed since the first patient with end stage renal disease received recombinant human erythropoietin (r-HuEPO). During this time many thousands of patients have been receiving r-HuEPO, and the knowledge of how to use EPO successfully and how to avoid adverse effects has been achieved. However, because of the costs of r-HuEPO, a great number of patients still lack beneficial effects of this treatment. The attempt to optimize the use of r-HuEPO in the treatment of chronic renal failure anemia could bring its benefits to a wider spectrum of patients. That is why we tried to summarize the answers to unresolved questions concerning r-HuEPO therapy that are already published. These are: when to start the treatment; what should be the target hemoglobin for patients receiving r-HuEPO, what route of administration should be used, what dosage will result in optimal response and what are the benefits expected. Identification and correction of reasons for failure of response to r-HuEPO therapy is important in ensuring the optimal use of EPO. The question is how common is iron deficiency, usually named as major cause for the hyporesponsiveness to EPO, and how should it be monitored and treated? What are the other causes of failure to respond to r-HuEPO and how could they be avoided. Finally, we are presenting brief listing of possibilities of adjuvant therapy and new EPO mimetic. ." @default.
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- W108014107 title "Optimizing the erythropoietin use in chronic renal failure patients" @default.
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