FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W108219953> ?p ?o ?g. }

• W108219953 abstract "Multiple sclerosis (MS) is a chronic, demyelinating condition of the central nervous system, manifesting in alteration or loss of motor, sensory and cognitive function. The causes of MS are unclear but include genetic and environmental factors. This thesis presents several epidemiologic analyses, examining MS geoepidemiology, locally and globally, as well as evaluating key environmental and infectious determinants of clinical course.The first analysis chapter examines MS epidemiology in the Greater Hobart region of Tasmania over the interval 1951 to 2009. This analysis found a significant increase in prevalence, this mediated by a significantly decreased mortality and increased longevity, as well as evidence of an increasing female/male sex ratio.Next is a meta-analysis of MS prevalence and its association with latitude. This work, utilising the largest collection of MS prevalence studies, found a significant positive association between MS prevalence and latitude. This provides evidence in favour of the latitudinal gradient hypothesis and for environmental factors underlying the gradient, most particularly personal ultraviolet radiation (UVR) exposure and vitamin D.The association between serum 25-hydroxyvitamin D (25(OH)D) and relapse was examined in a prospective cohort with clinically-definite MS followed for 2.3 years. This analysis found a significant inverse association between higher levels of 25(OH)D and subsequent hazard of relapse. This study provides key evidence that is needed to justify conducting randomised clinical trials of vitamin D supplementation in reducing relapse frequency in MS.In this MS cohort, it was also found that persons on interferon-β (IFN-β) therapy had significantly higher 25(OH)D levels and that the association between personal sun exposure and 25(OH)D was stronger compared to those not on IFN-β. Importantly, the above association between 25(OH)D and relapse was only observed for those on IFN-β therapy.Last is an examination of the role of antibodies to Human Herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) in MS clinical course. This analysis found a significant positive association between anti-HHV-6 I(_g)G and relapse. This effect persisted on adjustment for the anti-EBV I(_g)Gs, indicating the effect was specific for HHV-6 antigen, or host antigen resembling it. There was no evidence of frequent serological HHV-6 reactivation, suggesting that the observed association between anti-HHV-6 I(_g)G and relapse was not being mediated by serologically-detectable peripheral reactivation of HHV-6. No associations were observed between anti-HHV-6 and anti-EBV I(_g)Gs and progression in clinical disability.This thesis presents a range of studies which add significantly to the literature on MS geoepidemiology, as well as the associations of environmental and infectious factors on MS clinical course. This work will be useful in the scientific community; both for hypothesis generation and providing strong evidence in support of existing hypotheses, and hopefully be of benefit to people with this debilitating disease." @default.
• W108219953 created "2016-06-24" @default.
• W108219953 creator A5039297927 @default.
• W108219953 date "2011-01-01" @default.
• W108219953 modified "2023-09-27" @default.
• W108219953 title "On the geoepidemiology of multiple sclerosis and environmental and infectious determinants of its clinical course" @default.
• W108219953 hasPublicationYear "2011" @default.
• W108219953 type Work @default.
• W108219953 sameAs 108219953 @default.
• W108219953 citedByCount "0" @default.
• W108219953 crossrefType "dissertation" @default.
• W108219953 hasAuthorship W108219953A5039297927 @default.
• W108219953 hasConcept C124490489 @default.
• W108219953 hasConcept C126322002 @default.
• W108219953 hasConcept C144024400 @default.
• W108219953 hasConcept C149923435 @default.
• W108219953 hasConcept C188816634 @default.
• W108219953 hasConcept C201903717 @default.
• W108219953 hasConcept C203014093 @default.
• W108219953 hasConcept C207103383 @default.
• W108219953 hasConcept C2780640218 @default.
• W108219953 hasConcept C42407357 @default.
• W108219953 hasConcept C44249647 @default.
• W108219953 hasConcept C71924100 @default.
• W108219953 hasConcept C72563966 @default.
• W108219953 hasConceptScore W108219953C124490489 @default.
• W108219953 hasConceptScore W108219953C126322002 @default.
• W108219953 hasConceptScore W108219953C144024400 @default.
• W108219953 hasConceptScore W108219953C149923435 @default.
• W108219953 hasConceptScore W108219953C188816634 @default.
• W108219953 hasConceptScore W108219953C201903717 @default.
• W108219953 hasConceptScore W108219953C203014093 @default.
• W108219953 hasConceptScore W108219953C207103383 @default.
• W108219953 hasConceptScore W108219953C2780640218 @default.
• W108219953 hasConceptScore W108219953C42407357 @default.
• W108219953 hasConceptScore W108219953C44249647 @default.
• W108219953 hasConceptScore W108219953C71924100 @default.
• W108219953 hasConceptScore W108219953C72563966 @default.
• W108219953 hasLocation W1082199531 @default.
• W108219953 hasOpenAccess W108219953 @default.
• W108219953 hasPrimaryLocation W1082199531 @default.
• W108219953 hasRelatedWork W2020395055 @default.
• W108219953 hasRelatedWork W2048397314 @default.
• W108219953 hasRelatedWork W2051269760 @default.
• W108219953 hasRelatedWork W2054394441 @default.
• W108219953 hasRelatedWork W2069479645 @default.
• W108219953 hasRelatedWork W2073578396 @default.
• W108219953 hasRelatedWork W210261192 @default.
• W108219953 hasRelatedWork W2106370629 @default.
• W108219953 hasRelatedWork W2130025583 @default.
• W108219953 hasRelatedWork W2196163632 @default.
• W108219953 hasRelatedWork W2403255386 @default.
• W108219953 hasRelatedWork W2593576640 @default.
• W108219953 hasRelatedWork W2721186471 @default.
• W108219953 hasRelatedWork W2890550983 @default.
• W108219953 hasRelatedWork W2970137063 @default.
• W108219953 hasRelatedWork W3016663663 @default.
• W108219953 hasRelatedWork W3162227700 @default.
• W108219953 hasRelatedWork W3180428024 @default.
• W108219953 hasRelatedWork W3193477349 @default.
• W108219953 hasRelatedWork W592566100 @default.
• W108219953 isParatext "false" @default.
• W108219953 isRetracted "false" @default.
• W108219953 magId "108219953" @default.
• W108219953 workType "dissertation" @default.