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• W1082260189 abstract "Abstract Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation and functions in the central nervous system (CNS). Because BDNF protein is sorted into secretory vesicles at the trans-Golgi network in the cell body after translation, transport of BDNF-containing vesicles to the secretion sites is an important process for its function. Here we examined the effect of dexamethasone (DEX), a synthetic glucocorticoid, on BDNF-containing vesicle transport and found that DEX decreased the proportion of stationary vesicles and increased velocity of the microtubule-based vesicle transport in dendrites of cortical neurons. Furthermore, DEX increased huntingtin (Htt) protein levels via glucocorticoid receptor (GR) activation and reduction in the amount of Htt by a specific shRNA reversed the action of DEX on BDNF vesicle transport. Given that Htt protein is a positive regulator for the microtubule-dependent vesicular transport in neurons, our data suggest that glucocorticoid stimulates BDNF vesicle transport through upregulation of Htt protein levels." @default.
• W1082260189 created "2016-06-24" @default.
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• W1082260189 date "2015-08-04" @default.
• W1082260189 modified "2023-10-01" @default.
• W1082260189 title "Glucocorticoid affects dendritic transport of BDNF-containing vesicles" @default.
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• W1082260189 doi "https://doi.org/10.1038/srep12684" @default.
• W1082260189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4523857" @default.
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• W1082260189 hasPublicationYear "2015" @default.
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