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- W108242883 abstract "Since stem-loops are typical target RNA motifs by theheteroconjugates, a stem with a small bulge might be anotherpossible tagret. In order to test this idea a m, odel structure of16S rRNA A-site was chosen. This target RNA is composedof a stem with two bulges and an artificial short terminalloop (Figure 2). Since the binding site of neomycin B wasdefined in the upper stem region, heteroconjugates wouldmake anothe inr teactr ionw thi either a bugloe a lo r op reongiRNA, resulting in enhanced affinities relative to neomycinB In th. isre port we, describe the binding afnieiostif f NC (orNL ) heteroconjugates to models of 16S rRNA A-site. Morethan 20 times of affinity enhancement by selected hetero-conjugates was observed.Model RNAs of 16S rRNA A-site of bacteria and of 18SrRNA A-site, a human analogue" @default.
- W108242883 created "2016-06-24" @default.
- W108242883 date "2006-10-20" @default.
- W108242883 modified "2023-09-26" @default.
- W108242883 title "Enhanced Binding Affinity of Neomycin-Chloramphenicol (or Linezolid) Conjugates to A-Site Model of 16S Ribosomal RNA" @default.
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- W108242883 doi "https://doi.org/10.5012/bkcs.2006.27.10.1664" @default.
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