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• W108269217 abstract "Mucus is a highly hydrated uniquely structured gel that in conjunction with the ciliated cells in the surface epithelium forms the mucociliary clear­ance system essential for the protection of the respiratory tract [1]. The polymer matrix of the mucus biofilm is provided by very large complex glycoproteins that were formerly known as mucus glycoproteins but which are now commonly referred to as mucins [2-7]. Mucins are high-M„ extensively 0-linked glycoproteins of exceptional mass size and daunting complexity that are synthesised by cells in both the surface epithelium and in the underlying submucosal glands. In normal airways mucus production asthma, cystic fibrosis and chronic bronchitis, mucus hypersecretion may cause major problems in airway clearance, resulting in impaired gas exchange and bacterial colonisation leading to infection and lung damage. In this chapter we will focus on the large polymeric mucins that are responsible for the formation of the gel-like protective barrier in human airways." @default.
• W108269217 created "2016-06-24" @default.
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• W108269217 date "1997-01-01" @default.
• W108269217 modified "2023-10-18" @default.
• W108269217 title "Structure and Biochemistry of Human Respiratory Mucins" @default.
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• W108269217 doi "https://doi.org/10.1007/978-3-0348-8874-5_2" @default.
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