FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1082854877> ?p ?o ?g. }

• W1082854877 endingPage "1685" @default.
• W1082854877 startingPage "1676" @default.
• W1082854877 abstract "Electrochemistry (EC) combined with mass spectrometry (MS) is a powerful tool for elucidation of electrochemical reaction mechanisms. However, direct online analysis of electrochemical reaction in aqueous phase was rarely explored. This paper presents the online investigation of several electrochemical reactions with biological relevance in the aqueous phase, such as nitrosothiol reduction, carbohydrate oxidation, and carbamazepine oxidation using desorption electrospray ionization mass spectrometry (DESI-MS). It was found that electroreduction of nitrosothiols [e.g., nitrosylated insulin B (13-23)] leads to free thiols by loss of NO, as confirmed by online MS analysis for the first time. The characteristic mass shift of 29 Da and the reduced intensity provide a quick way to identify nitrosylated species. Equally importantly, upon collision-induced dissociation (CID), the reduced peptide ion produces more fragment ions than its nitrosylated precursor ion (presumably the backbone fragmentation cannot compete with the facile NO loss for the precursor ion), thus facilitating peptide sequencing. In the case of saccharide oxidation, it was found that glucose undergoes electro-oxidation to produce gluconic acid at alkaline pH, but not at neutral and acidic pHs. Such a pH-dependent electrochemical behavior was also observed for disaccharides such as maltose and cellobiose. Upon electrochemical oxidation, carbamazepine was found to undergo ring contraction and amide bond cleavage, which parallels the oxidative metabolism observed for this drug in leucocytes. The mechanistic information of these redox reactions revealed by EC/DESI-MS would be of value in nitroso-proteome research and carbohydrate/drug metabolic studies." @default.
• W1082854877 created "2016-06-24" @default.
• W1082854877 creator A5001016059 @default.
• W1082854877 creator A5014235806 @default.
• W1082854877 creator A5022499603 @default.
• W1082854877 creator A5042576858 @default.
• W1082854877 creator A5072525949 @default.
• W1082854877 creator A5075881249 @default.
• W1082854877 date "2015-08-05" @default.
• W1082854877 modified "2023-09-23" @default.
• W1082854877 title "Online Investigation of Aqueous-Phase Electrochemical Reactions by Desorption Electrospray Ionization Mass Spectrometry" @default.
• W1082854877 cites W145224721 @default.
• W1082854877 cites W1498196283 @default.
• W1082854877 cites W1541205806 @default.
• W1082854877 cites W1966639504 @default.
• W1082854877 cites W1968547171 @default.
• W1082854877 cites W1969626310 @default.
• W1082854877 cites W1969678794 @default.
• W1082854877 cites W1971745145 @default.
• W1082854877 cites W1976901141 @default.
• W1082854877 cites W1979696259 @default.
• W1082854877 cites W1982030738 @default.
• W1082854877 cites W1989496676 @default.
• W1082854877 cites W1990522746 @default.
• W1082854877 cites W1997626427 @default.
• W1082854877 cites W2000721981 @default.
• W1082854877 cites W2000745889 @default.
• W1082854877 cites W2002192155 @default.
• W1082854877 cites W2010554317 @default.
• W1082854877 cites W2012619004 @default.
• W1082854877 cites W2012800452 @default.
• W1082854877 cites W2017650671 @default.
• W1082854877 cites W2018122317 @default.
• W1082854877 cites W2021123817 @default.
• W1082854877 cites W2023531044 @default.
• W1082854877 cites W2027277050 @default.
• W1082854877 cites W2030321329 @default.
• W1082854877 cites W2037732568 @default.
• W1082854877 cites W2040677997 @default.
• W1082854877 cites W2041393785 @default.
• W1082854877 cites W2041646756 @default.
• W1082854877 cites W2043063119 @default.
• W1082854877 cites W2043599923 @default.
• W1082854877 cites W2047096849 @default.
• W1082854877 cites W2048640832 @default.
• W1082854877 cites W2049122955 @default.
• W1082854877 cites W2052016457 @default.
• W1082854877 cites W2052658122 @default.
• W1082854877 cites W2052684443 @default.
• W1082854877 cites W2055734180 @default.
• W1082854877 cites W2060343651 @default.
• W1082854877 cites W2067220642 @default.
• W1082854877 cites W2073593066 @default.
• W1082854877 cites W2074720780 @default.
• W1082854877 cites W2074976314 @default.
• W1082854877 cites W2076879455 @default.
• W1082854877 cites W2079337087 @default.
• W1082854877 cites W2080954351 @default.
• W1082854877 cites W2084238255 @default.
• W1082854877 cites W2085905023 @default.
• W1082854877 cites W2088584622 @default.
• W1082854877 cites W2090727772 @default.
• W1082854877 cites W2090750352 @default.
• W1082854877 cites W2092317584 @default.
• W1082854877 cites W2093739864 @default.
• W1082854877 cites W2094227333 @default.
• W1082854877 cites W2102469012 @default.
• W1082854877 cites W2141522397 @default.
• W1082854877 cites W2142219199 @default.
• W1082854877 cites W2143398388 @default.
• W1082854877 cites W2153980546 @default.
• W1082854877 cites W2157520165 @default.
• W1082854877 cites W2158273624 @default.
• W1082854877 cites W2159199618 @default.
• W1082854877 cites W2172110796 @default.
• W1082854877 cites W2320688158 @default.
• W1082854877 cites W2321411103 @default.
• W1082854877 cites W2328413295 @default.
• W1082854877 cites W2334925350 @default.
• W1082854877 cites W4362231430 @default.
• W1082854877 cites W85495494 @default.
• W1082854877 cites W2644804608 @default.
• W1082854877 doi "https://doi.org/10.1007/s13361-015-1210-2" @default.
• W1082854877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26242804" @default.
• W1082854877 hasPublicationYear "2015" @default.
• W1082854877 type Work @default.
• W1082854877 sameAs 1082854877 @default.
• W1082854877 citedByCount "15" @default.
• W1082854877 countsByYear W10828548772016 @default.
• W1082854877 countsByYear W10828548772017 @default.
• W1082854877 countsByYear W10828548772019 @default.
• W1082854877 countsByYear W10828548772020 @default.
• W1082854877 countsByYear W10828548772021 @default.
• W1082854877 countsByYear W10828548772022 @default.
• W1082854877 countsByYear W10828548772023 @default.
• W1082854877 crossrefType "journal-article" @default.
• W1082854877 hasAuthorship W1082854877A5001016059 @default.
• W1082854877 hasAuthorship W1082854877A5014235806 @default.

• next