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- W108587577 abstract "Nucleoside salvage in nucleotide biosynthesis is a subject of great concern in cancer chemotherapy. Antimetabolites that currently used for cancer treatment inhibit de nono pathways of nucleotide synthesis fail to block nucleoside salvage pathways. Nucleoside transport is the first step in the process of nucleoside salvage. It has been demonstrated that dipyridamole, an inhibitor of nucleoside transport, potentiated the effects of antimetabo-lite. 1–4 A number of compounds of natural origin including green tea polyphenols, salviano-lic acid A, antibiotics C3368-A and C3368-B were found to be active nucleoside transport inhibitors and acting as biochemical modulators.5–7 In recent years nucleoside transporter has been set as the molecular target for new drug research in our laboratory. Because of the high diversity of climate conditions and vegetations in Yunnan Province, China, one of our projects was to investigate novel nucleoside transport inhibitors or nucleoside analogs produced by actinomycetes which were isolated from this area. Yunnanmycin was detected after screening of 5,000 fermentation liquor samples from actinomycetes." @default.
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- W108587577 date "1998-01-01" @default.
- W108587577 modified "2023-09-27" @default.
- W108587577 title "Antitumor Activity of Yunnanmycin" @default.
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- W108587577 doi "https://doi.org/10.1007/978-1-4615-5381-6_111" @default.
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