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- W108636900 abstract "With the possible exeption of the placenta the liver performs a greater variety of metabolic reactions than any other organ in the body. It may be for that reason that Nature secured functional stability by providing the hepatic cell with a long average life span (for approximately 150 days). Consequently, in a liver not stimulated by any mitogenic agent the incidence of mitosis is very low (ranging from 0.005 to 0.05%) and most of the hepatic cells can be said to be in a quiescent stage or G0. The liver has substantial function reserve. If 3/4’s of the organ are excised, unless challanged, the animal’s body homeostasis is little affected. Still Nature does not wish to take any chances, it quickly compensates for the cell loss by hypertrophy followed by hyperplasia (for review see Nancy Bucher 1963; van Lancker 1976, Alison 1986); albeit somewhat incorrectly, the restoration of the liver mass and function is referred to as liver regeneration. Liver regeneration provides investigators with a convenient model for the study of compensatory cell proliferation. However during the replications necessary for regeneration the hepatocyte continues to function as a differentiated cell (Friedman et al. 1984)." @default.
- W108636900 created "2016-06-24" @default.
- W108636900 creator A5035519148 @default.
- W108636900 date "1989-01-01" @default.
- W108636900 modified "2023-09-27" @default.
- W108636900 title "Molecular Events in Liver Regeneration and Repair" @default.
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