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- W108747217 abstract "Na, K-ATPase is believed to be the receptor for digitalis glycosides. The authors have previously documented that C17 side group of the cardenolide molecule is crucial to ..cap alpha.. subunit receptor binding. They have attempted to identify the structure of this binding site by labelling the enzyme with a /sup 3/H-labelled photoactive probe localized in the C17 side group of the genin molecule. /sup 3/H-..cap alpha..-subunit was purified and subjected to tryptic digestion. The digest was fractionated by gel filtration on Sephadex G-100. Fractions containing /sup 3/H-labelled peptide were pooled and rechromatographed. The central peak fractions of /sup 3/H-peptide were pooled, analyzed by SDS-PAGE, and subjected to amino acid sequence analysis. The tryptic peptide containing the /sup 3/H-probe showed considerable sequence heterogeneity. Comparison of the sequence data with the published cDNA-based ..cap alpha..-subunit sequence revealed that this peptide material was indeed a mixture of two tryptic peptides of nearly identical size containing the sequences from residue 68 through residue 146, and residues 263 through 342. The latter peptide contains the sequence ... glu tyr thr try leu glu ... speculated by Shull et al. as a possible ouabain binding site." @default.
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- W108747217 date "1986-05-01" @default.
- W108747217 modified "2023-09-24" @default.
- W108747217 title "Studies on the digitalis binding site in Na, K-ATPase" @default.
- W108747217 hasPublicationYear "1986" @default.
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