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- W108800819 abstract "Publisher Summary This chapter presents study focusing on 1-methyl-,1,2,3,4-tetrahydro-β-carboline in man after alcohol drinking. l,2,3,4-tetrahydro-β-carboline (THBC, tryptoline, tetrahydronorharman), the condensation product of tryptamine and formaldehyde, has been found to be a normal constituent in human urine, plasma, and platelets as well as in rat brain. Small concentrations of THBC have been shown to increase the drinking of ethanol in rats. 1-methyl-THBC in pharmacological tests shows similar actions to other THBCs: being a moderate inhibitor of MAO-A and of the uptake of 5HT and inhibits apomorphine-induced stereotypies in rats (used as an animal model of paranoid schizophrenia). The chapter discusses the occurrence of 1-methyl-THBC in cerebrospinal fluid (CSF) as well as the correlation of its concentrations with those of ethanol and acetaldehyde are studied. It remains to be seen if the formation of 1-methyl-THBC (and/or the corresponding product from 5HT and 5-methoxytryptamine) can be shown to take part in the effects of ethanol, particularly in the dependence." @default.
- W108800819 created "2016-06-24" @default.
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- W108800819 date "1980-01-01" @default.
- W108800819 modified "2023-09-23" @default.
- W108800819 title "1-METHYL-,1,2,3,4-TETRAHYDRO-β-CARBOLINE IN MAN AFTER ALCOHOL DRINKING" @default.
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- W108800819 doi "https://doi.org/10.1016/b978-0-08-025921-5.50192-2" @default.
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