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- W108875941 abstract "The continuous alpha-neurotoxin-binding regions on the extracellular part (residues 1-210) of the alpha-chain of Torpedo californica acetylcholine receptor were localized by reaction of 125I-labelled alpha-bungarotoxin with synthetic overlapping peptides spanning this entire part of the chain. The specificity of the binding was confirmed by inhibition with unlabelled toxin and, for appropriate peptides, with unlabelled anti-(acetylcholine receptor) antibodies. Five toxin-binding regions were localized within residues 1-10, 32-41, 100-115, 122-150 and 182-198. The third, fourth and fifth (and to a lesser extent the first and second) toxin-binding regions overlapped with regions recognized by anti-(acetylcholine receptor) antibodies. The five toxin-binding regions may be distinct sites or, alternatively, different 'faces' in one (or more) sites." @default.
- W108875941 created "2016-06-24" @default.
- W108875941 creator A5018736664 @default.
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- W108875941 date "1987-12-15" @default.
- W108875941 modified "2023-09-25" @default.
- W108875941 title "Profile of the α-bungarotoxin-binding regions on the extracellular part of the α-chain of <i>Torpedo californica</i> acetylcholine receptor" @default.
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- W108875941 doi "https://doi.org/10.1042/bj2480847" @default.
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