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- W109015560 abstract "RKIP inhibits Raf-1 kinase activity and regulates MAPK signalling. It can also function via GPCR and the NK-κB signalling pathway. RKIP downregulation creates chromosomal instability and abnormalities. RKIP suppresses invasion and metastasis by regulating EMT, angiogenesis and apoptosis. Loss of RKIP expression occurs frequently in cancer. It interacts with Notch and Wnt signalling and can influence EMT activation by this route. The benefits of inducing the re-expression of RKIP on tumour biology are obvious, but there is little discernible effort." @default.
- W109015560 created "2016-06-24" @default.
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- W109015560 date "2013-01-01" @default.
- W109015560 modified "2023-09-25" @default.
- W109015560 title "RKIP Suppresses Invasion and Metastasis" @default.
- W109015560 doi "https://doi.org/10.1016/b978-0-12-416570-0.00022-6" @default.
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