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- W109051875 abstract "Traditional medical therapy relies on small-molecule drugs as therapeutic agents. These compounds are obtained either by serendipity, or by screens of natural products such as those produced by plants and fungi, or, more recently, by screens of synthetic combinatorial chemical libraries. Whereas most early efforts utilized cumbersome screens and bioassays, the modern version of drug discovery depends on high-throughput screens using in vitro assays with purified targets. Often used in combination with structure-based methods and quantitative structure-activity relationship (QSAR) techniques, this current preferred approach to drug discovery has been called rational design. Rational design demands known targets, and thus, there is a premium on good, validated targets to begin the drug development process." @default.
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- W109051875 date "2001-01-01" @default.
- W109051875 modified "2023-09-23" @default.
- W109051875 title "Drug Discovery and Gene Discovery" @default.
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- W109051875 doi "https://doi.org/10.1007/978-1-59259-107-7_12" @default.
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