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- W10911214 abstract "Ideas of I.I Mechnikov stated in biologic theory of inflammation and, specifically, about leading role of phagocytic are getting more and more prevalent. Special attention is paid to study of Toll-like receptors (TLRs) and cytokines roles in initiation of inflammatory reaction. TLRs are present not only on immune system's but virtually on all of an organism. On the basis of these data we proposed the hypothesis designated as one receptor-many cells and one receptor-one cell. In the former case the leading role in recognition of antigen belongs to TLRs then followed by other organism's cells, which is characteristic for innate immunity. In the latter case recognition is realized through T- and B-cell receptor presented only on lymphocytes, which is characteristic for adaptive immunity. New class of lipid mediators (rezlovins, protectins etc.) involved in stage of inflammation resolve is revealed. This means that drugs with antiinflammatory activity can act according to principle go-stop. Complex of natural cytokines and cationic antimicrobial peptides (Superlymph) possesses such effect." @default.
- W10911214 created "2016-06-24" @default.
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- W10911214 date "2008-09-01" @default.
- W10911214 modified "2023-09-27" @default.
- W10911214 title "[Theory of inflammation in light of new data: development of I.I Mechnikov ideas]." @default.
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