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- W109303770 abstract "SUMMARY Lymphocytotoxic activity could be demonstrated in the sera of patients withsystemic lupus erythematosus. The number of positive reactions varied withtemperature of incubation. Lymphocytotoxicity was present in 88%, 49%/ and 110% ofseratested at 15'C,220Cand370Crespectively. Atan incubation tempera-ture of 220C, the presence ofthe lymphocytotoxic antibody in the sera could becorrelatedwithsignificantlyhighertitresofanti-nuclearfactor,anti-single-strandedDNAandthehistological appearanceofactive diffuse glomerulonephritis in renal biopsies. INTRODUCTIONLymphocytotoxicantibodies havebeendemonstratedintheserumofpatientswithsystemiclupus erythematosus (Mittal et al., 1970; Terasaki, Mottironi B Stastny &Ziff, 1971). Theexact clinical andbiological significance ofthis antibodyis obscure. Thereis some evidence that the presence ofthe antibody is related to specific organ damage inSLE(Butleretal., 1972). Thiscommunicationreports onrelationships betweenthepresenceof this antibody and (1) titres of anti-nuclear factor, (2) presence of abnormal levels ofantibody to single-stranded DNA(anti-SSDNA), and (3) the nature ofthe renal involve-ment." @default.
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- W109303770 date "1974-06-01" @default.
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- W109303770 title "Lymphocytotoxic antibodies in patients with systemic lupus erythematosus." @default.
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