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- W1093049 abstract "Role of intracellular Ca2+ in the regulation of gap-junctional intercellular communication (GJIC) was investigated in cultured rabbit gastric epithelial cells. GJIC was measured by means of the dye-transfer using Lucifer Yellow CH and cytosolic free Ca2+ concentration ([Ca2+]i) was measured by means of the double wave length excitation using fura-2. lonomycin transiently decreased GJIC and increased [Ca2+]i in a concentration-dependent manner in the absence of extracellular Ca2+. 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced blockage of GJIC was abolished in the absence of extracellular Ca2+. Irsogladine suppressed the ionomycin-induced decrease of GJIC and increase of [Ca2+J]i. Irsogladine also inhibited TPA-induced blockage of GJIC. These results indicate that ionomycin-induced decrease of GJIC is due to the Ca2+ mobilization from the intracellular stores, and TPA-induced blockage of GJIC requires an influx of extracellular Ca2+ through the plasma membrane. Effect of irsogladine on ionomycin-induced decrease of GJIC may be produced by inhibition Ca2+ mobilization from the intracellular Ca2+ stores. In addition, irsogladine might inhibit the GJIC block induced by TPA by suppressing a Ca2+-mediated cellular response." @default.
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- W1093049 date "1995-01-01" @default.
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- W1093049 title "Intracellular calcium downregulates gap-junctional intercellular communication in cultured rabbit gastric epithelial cells" @default.
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- W1093049 doi "https://doi.org/10.1016/b978-0-444-81929-1.50016-2" @default.
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