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• W109367433 abstract "Jelenleg kozel 100, kulonboző sugarerzekenysegű, daganatos betegek bőrbiopszias mintaibol kialakitott primer fibroblaszt kulturaval rendelkezunk. Tobb primer sejtkulturat sikerult immortalizalnunk az emberi telomeraz gen retrovirus vektor segitsegevel tortenő bevitelevel. Kivalasztott fibroblaszt kulturakban a teljes emberi genomot lefedő mikroarrayvel tanulmanyoztuk a 2 Gy gamma sugarzas hatasara kialakulo gen-expresszios valtozasokat. Megallapitottuk, hogy mindossze 30 olyan gen talalhato, amely minden fibroblaszt sejtben valaszol sugarhatasra. Az ionizalo sugarzas kis dozisok hatasara kialakulo genom instabilitast kivalto es bystander hatasat tanulmanyozva megallapitottuk, hogy az nincs osszefuggesben a sejtek sugarerzekenysegevel. Bystander sejtek gen-expresszios mintazatat tanulmanyozva megallapitottuk, hogy 655, 406, 152 es 619 gen műkodese valtozott meg 500, 100, 40 es 10 mGy sugar dozis hatasara. 15 olyan gent talaltunk, amely minden dozis hatasara megvaltoztatta műkodeset bystander sejtekben. Kimutattuk, hogy a TP53INP1 gen mind kozvetlen sugartalalatot szenvedett, mind pedig bystander sejtekben aktivalodik. A kis sugardozisok jelentős mertekben befolyasolhatjak az immunrendszer műkodeset. Megallapitottuk, hogy az immunrendszer egyes sejtjei relative sugarerzekenyek (CD8+), mig masok sugarrezisztensek (Treg sejtek). Mar 100 mGy alatti sugardozisok is befolyasolhatjak az antigen prezentalo dendritikus sejtek műkodeset. | We have established nearly 100 primary human fibroblast cell cultures with different radiation sensitivity from skin biopsies taken from cancer patients. Several primary cultures were immortalized by the introduction of the human telomerase gene into the cells by retroviral vectors. In selected fibroblast cultures we have investigated the radiation induced transcriptional responses after 2 Gy gamma radiations by whole genome microarrys. We have detected only 30 genes which responded to radiation in all investigated cell lines. By investigating low dose radiation-induced genome instability and bystander effect in primary fibroblasts, we have found no correlation with the radiation sensitivity of the cells. Transcriptional responses were investigated in bystander cells after irradiation with 500, 100, 40 and 10 mGy. Two hours after irradiation 655, 406, 152 and 619 genes responded to these doses, respectively. Fifteen genes responded to radiation at all applied doses. Interestingly, TP53INP1 was activated both in directly irradiated and bystander cells. Low dose irradiation can seriously affect the immune system. We have found that certain lymphocyte subpopulations are relative radiation sensitive (CD8+ cells), while others are relative radiation resistant (Treg cells). The antigen presenting capacity of dendritic cells can be influenced by doses lower than 100 mGy." @default.
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• W109367433 date "2009-01-01" @default.
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• W109367433 title "A kis dózisú ionizáló sugárzás biológiai hatásai, az egyéni érzékenység szerepe a sugárhatásban. = Biological effects of low dose ionizing radiation, the effect of individual radiation susceptibility" @default.
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