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- W10947896 abstract "Pharmacogenomics is the study of how genetic differences influence the variability in patients’ responses to drugs. In recent years there have been many studies on the selection of pharmacogenomic biomarkers, in different populations in Europe and worldwide. We examined and compared the genome structure of the Greek population in regards to pharmacogenomic biomarkers and their incidence in that population to HapMap CEU population. A general study of 1936 pharmacogenomic biomarkers in 235 genes with pharmacogenomic interest was conducted in 50 healthy Greek individuals by using DMET+ microarray (Affymetrix, Santa Clara,CA,USA). Statistical analysis revealed 46 pharmacogenomic biomarkers showing statistical significance among those two populations (p<0.05). We expanded our study to ten European populations dividing them into subgroups according to the history and geography standards, i.e. the Balkans (Greece, Croatia, Serbia, and Slovenia), Central (Hungary, Slovenia, Poland, Czech Republic and Germany) and Southern Europe (Greece, Malta, Turkey). In that case our interest was channeled in the comparison of pharmacogenomic biomarkers among 20%-50% frequency of appearance. Finally, i) 123 important pharmacogenomic biomarkers in the subgroup of South Europe, ii) 103 in the subgroup of Balkans and iii) 106 in the sub-group of Central Europe were posing vast convergence among these countries.So with this study we expect to contribute to the rationalization of medication in these countries with possible reductions in medical costs. An additional step was the development of DruGeVar (http://drugevar.genomicmedicinealliance.org), an online database triangulating drugs with genes and pharmacogenomics biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics. The medical significance and economic value of a simple, predictive medicine response profile, which will provide information on the likelihood of efficacy and safety of a drug for an individual patient, will change the practice and economics of medicine." @default.
- W10947896 created "2016-06-24" @default.
- W10947896 creator A5022937494 @default.
- W10947896 date "2014-09-29" @default.
- W10947896 modified "2023-09-26" @default.
- W10947896 title "Συχνότητες φαρμακογονιδιωματικών δεικτών στον ελληνικό πληθυσμό : προεκτάσεις στη δημόσια υγεία" @default.
- W10947896 hasPublicationYear "2014" @default.
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