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• W109577046 abstract "Traditionally, medical imaging is applied to radiological diagnostics, i.e., to characterize a disease phenotype based on morphological or physiological readouts. Criteria determining image quality and, hence, its diagnostic value are spatial resolution and contrast-tonoise ratio (CNR), the ability to discriminate an anatomical structure from its environment. Image contrast is based on the biophysical properties of tissue such as absorption of radiation in X-ray, or proton density and spin relaxation in magnetic resonance imaging (MRI). Structure definition can be enhanced by administration of exogenous contrast agents, which are electron-dense materials for X-ray and para- or superparamagnetic compounds for MRI, the contract enhancement being governed by both the properties of the contrast agent and the tissue microstructure. The dynamic measurement of contrast changes induced by administration of a contrast agent provides information on physiological tissue parameters such as tissue perfusion, vascular permeability, and function of excretory organs. When combining the contrast-enhancing principle (reporter group) with a target-specific carrier moiety (receptor ligand, antibody, cell), specific information on target expression and function can be obtained. Such target-specific or molecular imaging approaches have raised considerable interest both from a diagnostic and therapeutic point-of-view (Rudin and Weissleder 2003). Considering the broad spectrum of applications of modern imaging technologies their increasing impact on drug discovery and development programs is not surprising." @default.
• W109577046 created "2016-06-24" @default.
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• W109577046 date "2004-01-01" @default.
• W109577046 modified "2023-09-27" @default.
• W109577046 title "Noninvasive Imaging in Drug Discovery and Development" @default.
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• W109577046 doi "https://doi.org/10.1007/978-3-662-07310-0_3" @default.
• W109577046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15248516" @default.

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