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- W109672310 abstract "The oxidative stress hypothesis of aging predicts that progression of the aging process could be retarded and the life spans of animals could be extended by decreases in oxidant production, enhancement of antioxidant defenses, or augmentation of repair capabilities. Some of the results from studies of Drosophila support this idea, but much of the existing evidence seems to be at odds with the most straightforward predictions of the hypothesis. In fact, the most conservative interpretation of the existing studies is that the predictions of the hypothesis need to be revised, in recognition of the physiological roles of oxidant production, the limited access of antioxidants to some sites of oxidant production, and the influence of confounding factors, such as altered rates of metabolism, in studies of life spans in poikilotherms, including Drosophila. Indeed, effects on life span alone do not provide a sufficient basis to infer the efficacy of any experimental treatment on mechanisms of aging in the poikilotherm. Consideration of such issues suggests that despite its wide appeal, further lines of investigation are necessary to verify or falsify the oxidative stress hypothesis." @default.
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- W109672310 date "2008-01-01" @default.
- W109672310 modified "2023-09-24" @default.
- W109672310 title "Roles of Oxidative Stress in the Aging Process of Drosophila melanogaster" @default.
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- W109672310 doi "https://doi.org/10.1007/978-1-59745-420-9_7" @default.
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