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• W109691321 abstract "Research Article1 December 1991free access Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. C. Nahmias C. Nahmias Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author N. Blin N. Blin Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author J.M. Elalouf J.M. Elalouf Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author M.G. Mattei M.G. Mattei Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author A.D. Strosberg A.D. Strosberg Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author L.J. Emorine L.J. Emorine Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author C. Nahmias C. Nahmias Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author N. Blin N. Blin Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author J.M. Elalouf J.M. Elalouf Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author M.G. Mattei M.G. Mattei Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author A.D. Strosberg A.D. Strosberg Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author L.J. Emorine L.J. Emorine Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. Search for more papers by this author Author Information C. Nahmias1, N. Blin1, J.M. Elalouf1, M.G. Mattei1, A.D. Strosberg1 and L.J. Emorine1 1Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France. The EMBO Journal (1991)10:3721-3727https://doi.org/10.1002/j.1460-2075.1991.tb04940.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The gene encoding the murine beta 3-adrenergic receptor (beta 3AR) has been isolated. It translates into a polypeptide of 388 amino acid residues which shows 82% overall homology with the human beta 3AR. In Southern blot experiments, a probe derived from the murine beta 3AR gene hybridizes to a unique restriction fragment in the murine and human genomes. In both species, the beta 3AR gene is located on chromosome 8, in regions (8A2----8A4 in mouse, and 8p11----8p12 in man) which are conserved between mouse and man. The pharmacological profile of the mouse beta 3AR strongly resembles that of the human beta 3AR. It is characterized by a low affinity toward the radiolabelled beta-adrenergic antagonist [125I]Iodocyanopindolol and a low efficiency of other antagonists such as propranolol, ICI 118551 or CGP 20712A to inhibit cAMP production induced by isoproterenol. Another salient feature shared by the murine and the human beta 3ARs is the very potent effect of the lipolytic compound BRL 37344 on cAMP accumulation and the partial agonistic effect of the beta 1- and beta 2-adrenergic antagonists CGP 12177A, oxprenolol and pindolol. These properties are very close to those ascribed to the atypical beta AR of rodent adipocytes. In addition, Northern blot analyses indicate that the beta 3AR gene is mainly expressed in mouse brown and white adipose tissues, suggesting that the murine beta 3AR described here is the atypical beta AR involved in the control of energy expenditure in fat tissue. Previous ArticleNext Article Volume 10Issue 121 December 1991In this issue RelatedDetailsLoading ..." @default.
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• W109691321 title "Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes." @default.
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