FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1097118004> ?p ?o ?g. }

• W1097118004 endingPage "336" @default.
• W1097118004 startingPage "328" @default.
• W1097118004 abstract "The mechanisms that control the selection of transcription initiation and termination sites in response to pharmacological stimulation of neuronal cells are poorly understood. We used next-generation sequencing and bioinformatics to construct a genome-wide inventory of protein-coding and non-coding transcripts altered by antidepressant treatment. We analyzed available ChIP-seq data to identify mechanisms that control drug-inducible expression of alternative gene variants in the brain. We identified 153 transcripts of various biotypes regulated in the mouse striatum in response to tranylcypromine or mianserin (at a 0.1% FDR threshold). Five drug-responsive gene patterns are enriched in protein-coding variants (77%), regulated by different sets of transcriptional factors (including SRF/CREB1 and GR/CTCF) and expressed in separate cellular compartments of the brain. We found that alterations mediated by proximal promoters in neurons are more specific in the selection of regulated transcriptional isoforms compared with enhancer-dependent alterations in glia. The change in transcriptional programs, from housekeeping to inducible, provides cells with the resource of functionally distinct proteins. We conclude that the regulation of drug-induced brain plasticity may occur at the level of transcripts rather than genes. The expression of specific isoforms in response to antidepressants may constitute a trigger that initiates the long-lasting effects of these drugs." @default.
• W1097118004 created "2016-06-24" @default.
• W1097118004 creator A5019755983 @default.
• W1097118004 creator A5021534068 @default.
• W1097118004 creator A5023124320 @default.
• W1097118004 creator A5025654219 @default.
• W1097118004 creator A5041505362 @default.
• W1097118004 creator A5054574320 @default.
• W1097118004 date "2015-12-01" @default.
• W1097118004 modified "2023-09-23" @default.
• W1097118004 title "Regulation of alternative gene transcription in the striatum in response to antidepressant drugs" @default.
• W1097118004 cites W117890930 @default.
• W1097118004 cites W1518755343 @default.
• W1097118004 cites W1966408021 @default.
• W1097118004 cites W1968605436 @default.
• W1097118004 cites W1989543331 @default.
• W1097118004 cites W1992284015 @default.
• W1097118004 cites W1993298019 @default.
• W1097118004 cites W1996493218 @default.
• W1097118004 cites W2001203903 @default.
• W1097118004 cites W2001944628 @default.
• W1097118004 cites W2006591182 @default.
• W1097118004 cites W2006917968 @default.
• W1097118004 cites W2008311225 @default.
• W1097118004 cites W2014787267 @default.
• W1097118004 cites W2023536589 @default.
• W1097118004 cites W2026743859 @default.
• W1097118004 cites W2030525076 @default.
• W1097118004 cites W2031403268 @default.
• W1097118004 cites W2033276865 @default.
• W1097118004 cites W2035857873 @default.
• W1097118004 cites W2037013399 @default.
• W1097118004 cites W2041867429 @default.
• W1097118004 cites W2042045791 @default.
• W1097118004 cites W2051219559 @default.
• W1097118004 cites W2052298346 @default.
• W1097118004 cites W2054275187 @default.
• W1097118004 cites W2056771515 @default.
• W1097118004 cites W2060542243 @default.
• W1097118004 cites W2069260947 @default.
• W1097118004 cites W2069274677 @default.
• W1097118004 cites W2070494252 @default.
• W1097118004 cites W2077129553 @default.
• W1097118004 cites W2084399551 @default.
• W1097118004 cites W2089084448 @default.
• W1097118004 cites W2093519416 @default.
• W1097118004 cites W2094074349 @default.
• W1097118004 cites W2100226042 @default.
• W1097118004 cites W2104626596 @default.
• W1097118004 cites W2111619522 @default.
• W1097118004 cites W2115235046 @default.
• W1097118004 cites W2116598561 @default.
• W1097118004 cites W2118151959 @default.
• W1097118004 cites W2130374405 @default.
• W1097118004 cites W2133332261 @default.
• W1097118004 cites W2133757476 @default.
• W1097118004 cites W2141458291 @default.
• W1097118004 cites W2141674392 @default.
• W1097118004 cites W2146634563 @default.
• W1097118004 cites W2148533858 @default.
• W1097118004 cites W2150901760 @default.
• W1097118004 cites W2155804510 @default.
• W1097118004 cites W2167807351 @default.
• W1097118004 cites W2168077701 @default.
• W1097118004 cites W2259938310 @default.
• W1097118004 cites W2318341725 @default.
• W1097118004 cites W4253478725 @default.
• W1097118004 doi "https://doi.org/10.1016/j.neuropharm.2015.08.006" @default.
• W1097118004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26254862" @default.
• W1097118004 hasPublicationYear "2015" @default.
• W1097118004 type Work @default.
• W1097118004 sameAs 1097118004 @default.
• W1097118004 citedByCount "7" @default.
• W1097118004 countsByYear W10971180042016 @default.
• W1097118004 countsByYear W10971180042017 @default.
• W1097118004 countsByYear W10971180042018 @default.
• W1097118004 countsByYear W10971180042019 @default.
• W1097118004 countsByYear W10971180042022 @default.
• W1097118004 crossrefType "journal-article" @default.
• W1097118004 hasAuthorship W1097118004A5019755983 @default.
• W1097118004 hasAuthorship W1097118004A5021534068 @default.
• W1097118004 hasAuthorship W1097118004A5023124320 @default.
• W1097118004 hasAuthorship W1097118004A5025654219 @default.
• W1097118004 hasAuthorship W1097118004A5041505362 @default.
• W1097118004 hasAuthorship W1097118004A5054574320 @default.
• W1097118004 hasConcept C101762097 @default.
• W1097118004 hasConcept C104317684 @default.
• W1097118004 hasConcept C111936080 @default.
• W1097118004 hasConcept C150194340 @default.
• W1097118004 hasConcept C165864922 @default.
• W1097118004 hasConcept C27153228 @default.
• W1097118004 hasConcept C53345823 @default.
• W1097118004 hasConcept C54355233 @default.
• W1097118004 hasConcept C86339819 @default.
• W1097118004 hasConcept C86803240 @default.
• W1097118004 hasConcept C95444343 @default.
• W1097118004 hasConceptScore W1097118004C101762097 @default.
• W1097118004 hasConceptScore W1097118004C104317684 @default.

• next