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- W109720786 endingPage "374" @default.
- W109720786 startingPage "343" @default.
- W109720786 abstract "Muscarinic agonists and antagonists are used to treat a handful of gastrointestinal (GI) conditions associated with impaired salivary secretion or altered motility of GI smooth muscle. With regard to exocrine secretion, the major muscarinic receptor expressed in salivary, gastric, and pancreatic glands is the M3 with a small contribution of the M1 receptor. In GI smooth muscle, the major muscarinic receptors expressed are the M2 and M3 with the M2 outnumbering the M3 by a ratio of at least four to one. The antagonism of both smooth muscle contraction and exocrine secretion is usually consistent with an M3 receptor mechanism despite the major presence of the M2 receptor in smooth muscle. These results are consistent with the conditional role of the M2 receptor in smooth muscle. That is, the contractile role of the M2 receptor depends on that of the M3 so that antagonism of the M3 receptor eliminates the response of the M2. The physiological roles of muscarinic receptors in the GI tract are consistent with their known signaling mechanisms. Some so-called tissue-selective M3 antagonists may owe their selectivity to a highly potent interaction with a nonmuscarinic receptor target." @default.
- W109720786 created "2016-06-24" @default.
- W109720786 creator A5004925894 @default.
- W109720786 creator A5024466186 @default.
- W109720786 creator A5069785329 @default.
- W109720786 date "2011-11-03" @default.
- W109720786 modified "2023-09-26" @default.
- W109720786 title "Muscarinic Agonists and Antagonists: Effects on Gastrointestinal Function" @default.
- W109720786 cites W1502294688 @default.
- W109720786 cites W1521991778 @default.
- W109720786 cites W1522474914 @default.
- W109720786 cites W1525041374 @default.
- W109720786 cites W1538630244 @default.
- W109720786 cites W1566493297 @default.
- W109720786 cites W1592061964 @default.
- W109720786 cites W1592314278 @default.
- W109720786 cites W1604562955 @default.
- W109720786 cites W1636290873 @default.
- W109720786 cites W1694838020 @default.
- W109720786 cites W1774459791 @default.
- W109720786 cites W1786056679 @default.
- W109720786 cites W1844605916 @default.
- W109720786 cites W1847954504 @default.
- W109720786 cites W1938705645 @default.
- W109720786 cites W1966547779 @default.
- W109720786 cites W1966640856 @default.
- W109720786 cites W1967340813 @default.
- W109720786 cites W1968058596 @default.
- W109720786 cites W1968519373 @default.
- W109720786 cites W1969259552 @default.
- W109720786 cites W1972351611 @default.
- W109720786 cites W1975019807 @default.
- W109720786 cites W1976166095 @default.
- W109720786 cites W1980970293 @default.
- W109720786 cites W1987827326 @default.
- W109720786 cites W1987971000 @default.
- W109720786 cites W1989165322 @default.
- W109720786 cites W1992993635 @default.
- W109720786 cites W1995519760 @default.
- W109720786 cites W1995645167 @default.
- W109720786 cites W2002494433 @default.
- W109720786 cites W2003567546 @default.
- W109720786 cites W2004844332 @default.
- W109720786 cites W2007044397 @default.
- W109720786 cites W2007829947 @default.
- W109720786 cites W2008616857 @default.
- W109720786 cites W2008873185 @default.
- W109720786 cites W2010425329 @default.
- W109720786 cites W2011976133 @default.
- W109720786 cites W2014670494 @default.
- W109720786 cites W2018462937 @default.
- W109720786 cites W2019277485 @default.
- W109720786 cites W2019372124 @default.
- W109720786 cites W2020091254 @default.
- W109720786 cites W2022189473 @default.
- W109720786 cites W2027704731 @default.
- W109720786 cites W2034408903 @default.
- W109720786 cites W2034656886 @default.
- W109720786 cites W2034964123 @default.
- W109720786 cites W2035864287 @default.
- W109720786 cites W2036719916 @default.
- W109720786 cites W2040227221 @default.
- W109720786 cites W2042403615 @default.
- W109720786 cites W2044531238 @default.
- W109720786 cites W2044940362 @default.
- W109720786 cites W2046194360 @default.
- W109720786 cites W2046983077 @default.
- W109720786 cites W2048260698 @default.
- W109720786 cites W2054225339 @default.
- W109720786 cites W2054514092 @default.
- W109720786 cites W2054716583 @default.
- W109720786 cites W2058412082 @default.
- W109720786 cites W2059390083 @default.
- W109720786 cites W2060209468 @default.
- W109720786 cites W2064076636 @default.
- W109720786 cites W2065817660 @default.
- W109720786 cites W2067309888 @default.
- W109720786 cites W2067322560 @default.
- W109720786 cites W2071554154 @default.
- W109720786 cites W2072205892 @default.
- W109720786 cites W2074606672 @default.
- W109720786 cites W2075535804 @default.
- W109720786 cites W2077408343 @default.
- W109720786 cites W2078565276 @default.
- W109720786 cites W2078958726 @default.
- W109720786 cites W2089891726 @default.
- W109720786 cites W2090095051 @default.
- W109720786 cites W2094364946 @default.
- W109720786 cites W2095107053 @default.
- W109720786 cites W2101369399 @default.
- W109720786 cites W2105391780 @default.
- W109720786 cites W2109033354 @default.
- W109720786 cites W2113368633 @default.
- W109720786 cites W2121872275 @default.
- W109720786 cites W2123365676 @default.
- W109720786 cites W2125966086 @default.
- W109720786 cites W2130505437 @default.
- W109720786 cites W2135339442 @default.