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- W109850329 abstract "Meiosis is a complex process involving one round of DNA replication followed by two rounds of cell divisions. The proper segregation of homologs at meiosis I and sister chromatids during meiosis II is essential for the survival of the offspring. Aberrant chromosome segregation at any stage of meiosis can lead to aneuploidy. Meiotic chromosome segregation without crossing over or chiasmata is a widespread but poorly understand chromosome segregation pathway. In male Drosophila meiosis the absence of recombination in chromosomes makes it easier to identify mutations which influence homologous chromosome pairing and segregation. Modifier of Mdg4 in Meiosis (MNM), a protein encoded by modifier of mdg4, is required for integrity of chromosome territories and stability of achiasmatic bivalents and for normal homolog segregation in male Drosophila meiosis I. MNM localizes to clusters of nucleolar and autosomal foci during meiotic prophase I (PI) and to a novel, compact structure associated with the X-Y bivalent during prometaphase I (PMI) and metaphase I (MI). Stromalin in Meiosis (SNM), a member of the SCC3/STAG cohesion family, is required for homolog pairing in male Drosophila but not for meiotic sister chromatid cohesin. SNM protein co-localizes with MNM to the nucleolus throughout PI and to a prominent focus on the X-Y bivalent during PMI and MI. Mutations of snm and mnm exhibit similar homolog pairing failure during meiosis I. Consequently we used the Yeast Two-Hybrid System to determine whether SNM and MNM can interact with each other. We concluded that MNM can interact with itself and SNM. We also found that SNM interacts with the" @default.
- W109850329 created "2016-06-24" @default.
- W109850329 creator A5060010551 @default.
- W109850329 date "2007-01-01" @default.
- W109850329 modified "2023-09-23" @default.
- W109850329 title "Studies on the Mechanisms of Homolog Pairing and Sister Chromatid Cohesion During Drosophila Male Meiosis" @default.
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