FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W109877653> ?p ?o ?g. }

• W109877653 endingPage "261" @default.
• W109877653 startingPage "252" @default.
• W109877653 abstract "Malignant hyperthermia is a life-threatening condition caused by autosomal dominant mutations in the ryanodine receptor type 1 gene. Identifying patients predisposed to malignant hyperthermia is done through the Ca-induced Ca release test in Japan. We examined the intracellular calcium concentration in human cultured muscle cells and compared the sensitivity of myotubes to ryanodine receptor type 1 activators based on the Ca-induced Ca release rate. We assessed the utility of this method as an identifying test for predisposition to malignant hyperthermia. Muscle specimens were obtained from 34 individuals undergoing the Ca-induced Ca release test. We cultured myotubes from residual material and monitored changes in intracellular calcium concentration after exposure to the ryanodine receptor type 1 activators caffeine, halothane and 4-chloro-m-cresol by measuring fura-2 fluorescence. We determined the half maximal effective concentrations (EC 50 ) for the test compounds in each myotube and calculated cut-off points using receiver operating characteristic curves. Seventeen patients each were classified into the accelerated and non-accelerated groups based on their Ca-induced Ca release rate. The EC 50 values for caffeine, halothane and 4-chloro-m-cresol of the accelerated group were significant lower than those of the non-accelerated group (P <0.001, P <0.001 and P <0.001, respectively). The calculated cut-off points of EC 50 values for caffeine, halothane and 4-CmC were 3.62 mM, 2.28 mM and 197 μM, respectively. An increased sensitivity to ryanodine receptor type 1 activators was seen in myotubes in the accelerated group. This functional test on human cultured myotubes indicates that the alteration of their intracellular Ca 2+ homeostasis may identify the predisposition to malignant hyperthermia." @default.
• W109877653 created "2016-06-24" @default.
• W109877653 creator A5014642732 @default.
• W109877653 creator A5014931333 @default.
• W109877653 creator A5022218831 @default.
• W109877653 creator A5036155653 @default.
• W109877653 creator A5042881709 @default.
• W109877653 creator A5075613958 @default.
• W109877653 date "2011-03-01" @default.
• W109877653 modified "2023-09-26" @default.
• W109877653 title "Analysis of Human Cultured Myotubes Responses Mediated by Ryanodine Receptor 1" @default.
• W109877653 cites W1558371851 @default.
• W109877653 cites W159217899 @default.
• W109877653 cites W1963782567 @default.
• W109877653 cites W1969960824 @default.
• W109877653 cites W1979306626 @default.
• W109877653 cites W1982091952 @default.
• W109877653 cites W1994500041 @default.
• W109877653 cites W1996008020 @default.
• W109877653 cites W1997314128 @default.
• W109877653 cites W2000931006 @default.
• W109877653 cites W2001481709 @default.
• W109877653 cites W2004018202 @default.
• W109877653 cites W2023974577 @default.
• W109877653 cites W2026461527 @default.
• W109877653 cites W2035808268 @default.
• W109877653 cites W2041746354 @default.
• W109877653 cites W2048551240 @default.
• W109877653 cites W2049376014 @default.
• W109877653 cites W2054761365 @default.
• W109877653 cites W2057598441 @default.
• W109877653 cites W2058998963 @default.
• W109877653 cites W2062840515 @default.
• W109877653 cites W2065170309 @default.
• W109877653 cites W2068316119 @default.
• W109877653 cites W2081447030 @default.
• W109877653 cites W2087955851 @default.
• W109877653 cites W2089980142 @default.
• W109877653 cites W2100493828 @default.
• W109877653 cites W2121481190 @default.
• W109877653 cites W2124905536 @default.
• W109877653 cites W2138251630 @default.
• W109877653 cites W2155842024 @default.
• W109877653 cites W2401910891 @default.
• W109877653 cites W36028778 @default.
• W109877653 cites W4211223349 @default.
• W109877653 cites W49376696 @default.
• W109877653 cites W2413479948 @default.
• W109877653 cites W4242605148 @default.
• W109877653 doi "https://doi.org/10.1177/0310057x1103900216" @default.
• W109877653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21485675" @default.
• W109877653 hasPublicationYear "2011" @default.
• W109877653 type Work @default.
• W109877653 sameAs 109877653 @default.
• W109877653 citedByCount "7" @default.
• W109877653 countsByYear W1098776532015 @default.
• W109877653 countsByYear W1098776532018 @default.
• W109877653 countsByYear W1098776532020 @default.
• W109877653 countsByYear W1098776532022 @default.
• W109877653 countsByYear W1098776532023 @default.
• W109877653 crossrefType "journal-article" @default.
• W109877653 hasAuthorship W109877653A5014642732 @default.
• W109877653 hasAuthorship W109877653A5014931333 @default.
• W109877653 hasAuthorship W109877653A5022218831 @default.
• W109877653 hasAuthorship W109877653A5036155653 @default.
• W109877653 hasAuthorship W109877653A5042881709 @default.
• W109877653 hasAuthorship W109877653A5075613958 @default.
• W109877653 hasBestOaLocation W1098776531 @default.
• W109877653 hasConcept C113217602 @default.
• W109877653 hasConcept C126322002 @default.
• W109877653 hasConcept C134018914 @default.
• W109877653 hasConcept C170493617 @default.
• W109877653 hasConcept C181080969 @default.
• W109877653 hasConcept C2776333580 @default.
• W109877653 hasConcept C2776932660 @default.
• W109877653 hasConcept C2778500429 @default.
• W109877653 hasConcept C2778575482 @default.
• W109877653 hasConcept C2779959927 @default.
• W109877653 hasConcept C3763915 @default.
• W109877653 hasConcept C42219234 @default.
• W109877653 hasConcept C519063684 @default.
• W109877653 hasConcept C71924100 @default.
• W109877653 hasConceptScore W109877653C113217602 @default.
• W109877653 hasConceptScore W109877653C126322002 @default.
• W109877653 hasConceptScore W109877653C134018914 @default.
• W109877653 hasConceptScore W109877653C170493617 @default.
• W109877653 hasConceptScore W109877653C181080969 @default.
• W109877653 hasConceptScore W109877653C2776333580 @default.
• W109877653 hasConceptScore W109877653C2776932660 @default.
• W109877653 hasConceptScore W109877653C2778500429 @default.
• W109877653 hasConceptScore W109877653C2778575482 @default.
• W109877653 hasConceptScore W109877653C2779959927 @default.
• W109877653 hasConceptScore W109877653C3763915 @default.
• W109877653 hasConceptScore W109877653C42219234 @default.
• W109877653 hasConceptScore W109877653C519063684 @default.
• W109877653 hasConceptScore W109877653C71924100 @default.
• W109877653 hasIssue "2" @default.
• W109877653 hasLocation W1098776531 @default.

• next