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- W1099204085 abstract "In 2014, Prostate cancer was the most commonly diagnosed cancer in men in the Western world, but few modifiable risk factors exist for this disease. Many studies have examined the association between obesity and prostate cancer incidence, producing conflicting results. However, maternal energetics during periconception and gestation has barely been considered as a potential risk factor, despite the fact that prostate tissue patterning and early development occur in utero. Maternal diabetes and obesity dramatically affect health at the time of pregnancy, and rodent and human studies demonstrate that the effects manifest in a variety of noncommunicable conditions in offspring, including early initiation of mammary tumors. Importantly, maternal diabetes and obesity directly alter the health of the early embryo and the maternal germ cell, or oocyte. Obesity-exposed oocytes exhibit alterations in size, gene expression, chromosome structure, and metabolism, and adult offspring present with defects including hyperplastic prostate tissues. We propose here that maternal obesity alters epigenetic and metabolic functions in the oocyte, which are passed to offspring, sensitizing them to precancerous conditions. Such an in utero environment could provide a “first hit” for prostate cancer development and should be considered when making dietary recommendations for expectant mothers." @default.
- W1099204085 created "2016-06-24" @default.
- W1099204085 creator A5000019972 @default.
- W1099204085 creator A5077415453 @default.
- W1099204085 date "2015-01-01" @default.
- W1099204085 modified "2023-09-23" @default.
- W1099204085 title "Maternal Energetics and the Developmental Origins of Prostate Cancer in Offspring" @default.
- W1099204085 cites W1537175468 @default.
- W1099204085 cites W1823225455 @default.
- W1099204085 cites W1864226267 @default.
- W1099204085 cites W1965069019 @default.
- W1099204085 cites W1967094568 @default.
- W1099204085 cites W1968300587 @default.
- W1099204085 cites W1968324924 @default.
- W1099204085 cites W1969044486 @default.
- W1099204085 cites W1969078544 @default.
- W1099204085 cites W1969312160 @default.
- W1099204085 cites W1971408353 @default.
- W1099204085 cites W1974491774 @default.
- W1099204085 cites W1976143235 @default.
- W1099204085 cites W1976611670 @default.
- W1099204085 cites W1978167545 @default.
- W1099204085 cites W1978337436 @default.
- W1099204085 cites W1980642844 @default.
- W1099204085 cites W1980836434 @default.
- W1099204085 cites W1982463875 @default.
- W1099204085 cites W1985541077 @default.
- W1099204085 cites W1986153378 @default.
- W1099204085 cites W1986154037 @default.
- W1099204085 cites W1987984705 @default.
- W1099204085 cites W1988061469 @default.
- W1099204085 cites W1988497434 @default.
- W1099204085 cites W1990651360 @default.
- W1099204085 cites W1991938926 @default.
- W1099204085 cites W1993389882 @default.
- W1099204085 cites W1999478182 @default.
- W1099204085 cites W2000307070 @default.
- W1099204085 cites W2001730981 @default.
- W1099204085 cites W2002233327 @default.
- W1099204085 cites W2002698073 @default.
- W1099204085 cites W2003217864 @default.
- W1099204085 cites W2004078197 @default.
- W1099204085 cites W2004873484 @default.
- W1099204085 cites W2005144653 @default.
- W1099204085 cites W2005902510 @default.
- W1099204085 cites W2007616778 @default.
- W1099204085 cites W2008669428 @default.
- W1099204085 cites W2009958409 @default.
- W1099204085 cites W2011123543 @default.
- W1099204085 cites W2011649969 @default.
- W1099204085 cites W2011813182 @default.
- W1099204085 cites W2012287006 @default.
- W1099204085 cites W2014662793 @default.
- W1099204085 cites W2015416439 @default.
- W1099204085 cites W2015455880 @default.
- W1099204085 cites W2022319307 @default.
- W1099204085 cites W2024498651 @default.
- W1099204085 cites W202561933 @default.
- W1099204085 cites W2031447136 @default.
- W1099204085 cites W2033250587 @default.
- W1099204085 cites W2033841021 @default.
- W1099204085 cites W2033878889 @default.
- W1099204085 cites W2034216887 @default.
- W1099204085 cites W2035380891 @default.
- W1099204085 cites W2040560580 @default.
- W1099204085 cites W2040762359 @default.
- W1099204085 cites W2041686632 @default.
- W1099204085 cites W2044648814 @default.
- W1099204085 cites W2047863383 @default.
- W1099204085 cites W2048002279 @default.
- W1099204085 cites W2049903859 @default.
- W1099204085 cites W2049984303 @default.
- W1099204085 cites W2050674280 @default.
- W1099204085 cites W2050705896 @default.
- W1099204085 cites W2051211149 @default.
- W1099204085 cites W2052351468 @default.
- W1099204085 cites W2059093027 @default.
- W1099204085 cites W2061444003 @default.
- W1099204085 cites W2061888284 @default.
- W1099204085 cites W2064117760 @default.
- W1099204085 cites W2066821096 @default.
- W1099204085 cites W2067066432 @default.
- W1099204085 cites W2070013658 @default.
- W1099204085 cites W2071592190 @default.
- W1099204085 cites W2074437918 @default.
- W1099204085 cites W2074599889 @default.
- W1099204085 cites W2075105799 @default.
- W1099204085 cites W2075991521 @default.
- W1099204085 cites W2078474243 @default.
- W1099204085 cites W2079474262 @default.
- W1099204085 cites W2082349539 @default.
- W1099204085 cites W2082573856 @default.
- W1099204085 cites W2088672580 @default.
- W1099204085 cites W2092488497 @default.
- W1099204085 cites W2093896423 @default.
- W1099204085 cites W2094527207 @default.
- W1099204085 cites W2096083625 @default.
- W1099204085 cites W2100953796 @default.