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- W110171612 abstract "Publisher SummaryThis chapter discusses hypoxanthine monitoring for detection of asphyxia in newborn infants. Exact proof of oxygen deficiency in newborn infants is of vital importance because oxygen insufficiency at birth may lead to brain damage or even to death. With an oxygen insufficiency in the blood of newborn infants, a metabolic product (hypoxanthine) will occur at higher concentration that can be established biochemically. The chapter describes the development of a biosensor for determining hypoxanthine concentration in umbilical cord blood plasma. It consists of two miniaturized oxygen-flow-through electrodes and an enzyme cartridge placed between these electrodes; the two enzymes xanthine-oxidase and catalase are bound covalently to activated controlled pore glass particles via glutardialdehyde. During the oxygen-consuming reaction of xanthine-oxidase, hydrogen peroxide is formed. However, the increase in hydrogen peroxide concentration cannot be used to calculate hypoxanthine concentration as there are catalase-like activities in human blood plasma that degrade an unknown part of hydrogen peroxide." @default.
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- W110171612 date "1992-01-01" @default.
- W110171612 modified "2023-09-27" @default.
- W110171612 title "HYPOXANTHINE MONITORING FOR DETECTION OF ASPHYXIA IN NEWBORN INFANTS" @default.
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- W110171612 doi "https://doi.org/10.1016/b978-1-85617-161-8.50073-2" @default.
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