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• W110230828 abstract "Back to table of contents Previous article Next article No AccessA relationship between anatomical and physiological brain pathology in schizophrenia: lateral cerebral ventricular size predicts cortical blood flowPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.144.10.1277AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractThe authors studied the relationship between lateral cerebral ventricular size and regional cerebral blood flow during mental activation in 30 patients with schizophrenia. Patients with large ventricles had diffusely lower cortical gray matter blood flow than patients with small ventricles. In addition, an inverse correlation between ventricular size and prefrontal blood flow was observed while patients were attempting to solve a neuropsychological test specifically related to the prefrontal cortex. These data suggest that structural brain pathology impairs prefrontal physiology in schizophrenia, implicating a neural mechanism for the intellectual deficits characteristic of this disorder. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byCognitive impairments in schizophrenia and their impact on oxidative stress15 October 2022 | V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, Vol. 56, No. 3Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia22 February 2018 | ACS Chemical Neuroscience, Vol. 9, No. 9Psychoneuroendocrinology, Vol. 51Psychiatric Disturbances of Attention10 July 2013Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 28, No. 5Magyar Pszichológiai Szemle, Vol. 55, No. 4Schizoaffective Disorder: A Case StudyJournal of Psychosocial Nursing and Mental Health Services, Vol. 33, No. 10CSF dopamine beta-hydroxylase in schizophrenia: associations with premorbid functioning and brain computerized tomography scan measures1 April 2006 | American Journal of Psychiatry, Vol. 151, No. 3Letters to the Editor7 July 2022 | Journal of the Royal Society of Medicine, Vol. 86, No. 4General Hospital Psychiatry, Vol. 15, No. 2Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 7Psychiatry Research: Neuroimaging, Vol. 45, No. 4Biological Psychiatry, Vol. 30, No. 9Biological Psychiatry, Vol. 29, No. 6Biological Psychiatry, Vol. 29, No. 5, Vol. 85Psychophysiology, Vol. 28, No. 5EEG power spectrum profile and structural CNS characteristics in schizophreniaBiological Psychiatry, Vol. 27, No. 12Biological Psychiatry, Vol. 27, No. 4Psychological Medicine, Vol. 20, No. 1Acta Psychiatrica Scandinavica, Vol. 81, No. 6British Journal of Psychiatry, Vol. 156, No. 5Psychiatry Research, Vol. 29, No. 2Psychiatry Research, Vol. 28, No. 2Psychiatry Research, Vol. 29, No. 3Schizophrenia Research, Vol. 2, No. 6Irish Journal of Psychological Medicine, Vol. 6, No. 1A Neurodiagnostlc Approach to Schizophrenia1 August 1988 | The Canadian Journal of Psychiatry, Vol. 33, No. 6Dr. Williamson Replies1 April 1988 | The Canadian Journal of Psychiatry, Vol. 33, No. 3 Volume 144Issue 10 October 1987Pages 1277-1282 Metrics PDF download History Published online 1 April 2006 Published in print 1 October 1987" @default.
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• W110230828 title "A relationship between anatomical and physiological brain pathology in schizophrenia: lateral cerebral ventricular size predicts cortical blood flow" @default.
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