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- W110281640 abstract "In the last decade, substantial scientific progress has enabled a better understanding of the pathogenesis of cerebellar diseases and the improvement of their diagnoses. Extensive preclinical work is expanding the possibilities of using experimental models to analyze disease-specific mechanisms and to approach candidate therapeutic strategies to create a rationale for clinical trials that might finally lead to successful treatment. At present, drug treatment of cerebellar disorders has shown limited effectiveness and current treatment is primarily A. Matilla-Duenas (*) Department of Neurosciences, Basic, Translational and Molecular Neurogenetics Research Unit, Health Sciences Research Institute Germans Trias I Pujol (IGTP), Universitat Autonoma de Barcelona, Ctra. de Can Ruti, Cami de les escoles s/n, 08916 Badalona (Barcelona), Spain e-mail: amatilla@btnunit.org, amatilla@igtp.cat C. Serrano Neurology Service, Hospital de Martorell, 08760 Barcelona, Spain e-mail: cserrano@hmartorell.es Y. Ivanovic Monte Alto Rehabilitation Medical Center, (Madrid), Private Practice, Calle Monte Alto 25, 28223, Madrid, Spain and National Reference Care Centre for People with Rare Diseases and Their Families–CREER–(Burgos), IMSERSO, Calle Bernardino Obregon, 09001 Burgos, Spain e-mail: yerko@yerkoivanovic.com, yerkoivanovic@gmail.com R. Alvarez • P. Latorre Neurodegeneration Unit, Neurology Service, University Hospital Germans Trias i Pujol (HUGTP), Badalona (Barcelona), Spain e-mail: ralvarez.germanstrias@gencat.cat, platorre.germanstrias@gencat.cat D. Genis Neurodegenerative Diseases Unit, University Hospital of Girona Dr. Josep Trueta, Girona, Spain e-mail: dgenis.girona.ics@gencat.cat M. Manto, D.L. Gruol, J.D. Schmahmann, N. Koibuchi, F. Rossi (eds.), Handbook of the Cerebellum and Cerebellar Disorders, DOI 10.1007/978-94-007-1333-8_106, # Springer Science+Business Media Dordrecht 2013 2371 supportive. Until effective and selective pharmacological treatment leading to better quality of life as well as increased survival of patients with cerebellar diseases is found, physical and sensory rehabilitation techniques are revealing effective approaches for improving the patient’s quality of life. The objective of this chapter is to provide an updated summary of the treatments currently available for cerebellar disorders, in particular for spinocerebellar ataxias, and to discuss the new emerging therapeutic strategies that are resulting from the intensive ongoing basic and translational research devoted to cerebellar diseases." @default.
- W110281640 created "2016-06-24" @default.
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- W110281640 date "2012-01-01" @default.
- W110281640 modified "2023-10-18" @default.
- W110281640 title "Novel Therapeutic Challenges in Cerebellar Diseases" @default.
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