Matches in SemOpenAlex for { <https://semopenalex.org/work/W110291916> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W110291916 abstract "Hydrolysis and chromatography of urine from male Sprague-Dawley rats injected with pyrazole-3,4−14C (PC14), and comparison with authentic material, have shown that the major metabolite of pyrazole (P) in rats is 4-hydroxypyrazole, excreted in hydrolyzable conjugated forms. Urinary unchanged P is usually less than 10% of the injected dose. The distribution of PC14 in 20 tissues 4 hours after IP injection of 1 mmole/kg PC14 showed low levels in fat (0.4 mM) and skin (0.9 mM) and high levels in stomach (4.4 mM); other tissues had levels of about 1 mM. Kinetics of P's disappearance from blood are complicated; the curves (after IP doses of 0.2, 1.0, 2.0, and 4.0 mmoles/kg) are sigmoidal and may indicate induction of a hydroxylating enzyme. When an IP dose of 2.0 mmoles/kg PC14 was given at various blood levels of ethanol (maintained by infusion), not only was alcohol metabolism greatly slowed, but P oxidation was essentially stopped at high (300 mg/100 ml) blood levels of ethanol; under these circumstances, the percentage of unchanged urinary P rose to 75%." @default.
- W110291916 created "2016-06-24" @default.
- W110291916 creator A5017207843 @default.
- W110291916 creator A5048793988 @default.
- W110291916 creator A5066919651 @default.
- W110291916 date "1977-01-01" @default.
- W110291916 modified "2023-10-17" @default.
- W110291916 title "METABOLISM OF PYRAZOLE IN THE RAT11Supported in part by AA18023." @default.
- W110291916 cites W1530163795 @default.
- W110291916 cites W1967660304 @default.
- W110291916 cites W1992310556 @default.
- W110291916 cites W2076377283 @default.
- W110291916 cites W2093009571 @default.
- W110291916 cites W2244127359 @default.
- W110291916 cites W2277022005 @default.
- W110291916 cites W2416407624 @default.
- W110291916 cites W3211952633 @default.
- W110291916 cites W65640609 @default.
- W110291916 doi "https://doi.org/10.1016/b978-0-12-691403-0.50044-6" @default.
- W110291916 hasPublicationYear "1977" @default.
- W110291916 type Work @default.
- W110291916 sameAs 110291916 @default.
- W110291916 citedByCount "12" @default.
- W110291916 countsByYear W1102919162019 @default.
- W110291916 crossrefType "book-chapter" @default.
- W110291916 hasAuthorship W110291916A5017207843 @default.
- W110291916 hasAuthorship W110291916A5048793988 @default.
- W110291916 hasAuthorship W110291916A5066919651 @default.
- W110291916 hasConcept C126322002 @default.
- W110291916 hasConcept C155647269 @default.
- W110291916 hasConcept C185592680 @default.
- W110291916 hasConcept C2777477808 @default.
- W110291916 hasConcept C2777682936 @default.
- W110291916 hasConcept C2779422922 @default.
- W110291916 hasConcept C2780026642 @default.
- W110291916 hasConcept C2780161600 @default.
- W110291916 hasConcept C2781066024 @default.
- W110291916 hasConcept C43617362 @default.
- W110291916 hasConcept C55493867 @default.
- W110291916 hasConcept C62231903 @default.
- W110291916 hasConcept C71924100 @default.
- W110291916 hasConcept C77411442 @default.
- W110291916 hasConcept C94412978 @default.
- W110291916 hasConcept C98274493 @default.
- W110291916 hasConceptScore W110291916C126322002 @default.
- W110291916 hasConceptScore W110291916C155647269 @default.
- W110291916 hasConceptScore W110291916C185592680 @default.
- W110291916 hasConceptScore W110291916C2777477808 @default.
- W110291916 hasConceptScore W110291916C2777682936 @default.
- W110291916 hasConceptScore W110291916C2779422922 @default.
- W110291916 hasConceptScore W110291916C2780026642 @default.
- W110291916 hasConceptScore W110291916C2780161600 @default.
- W110291916 hasConceptScore W110291916C2781066024 @default.
- W110291916 hasConceptScore W110291916C43617362 @default.
- W110291916 hasConceptScore W110291916C55493867 @default.
- W110291916 hasConceptScore W110291916C62231903 @default.
- W110291916 hasConceptScore W110291916C71924100 @default.
- W110291916 hasConceptScore W110291916C77411442 @default.
- W110291916 hasConceptScore W110291916C94412978 @default.
- W110291916 hasConceptScore W110291916C98274493 @default.
- W110291916 hasLocation W1102919161 @default.
- W110291916 hasOpenAccess W110291916 @default.
- W110291916 hasPrimaryLocation W1102919161 @default.
- W110291916 hasRelatedWork W1552321433 @default.
- W110291916 hasRelatedWork W1915985313 @default.
- W110291916 hasRelatedWork W1964786423 @default.
- W110291916 hasRelatedWork W1977307976 @default.
- W110291916 hasRelatedWork W1986198093 @default.
- W110291916 hasRelatedWork W1996790533 @default.
- W110291916 hasRelatedWork W2040462438 @default.
- W110291916 hasRelatedWork W2072473831 @default.
- W110291916 hasRelatedWork W2083871843 @default.
- W110291916 hasRelatedWork W2093210130 @default.
- W110291916 hasRelatedWork W2134710636 @default.
- W110291916 hasRelatedWork W2159518299 @default.
- W110291916 hasRelatedWork W2313273808 @default.
- W110291916 hasRelatedWork W2320118737 @default.
- W110291916 hasRelatedWork W2321673698 @default.
- W110291916 hasRelatedWork W2322971115 @default.
- W110291916 hasRelatedWork W2416156671 @default.
- W110291916 hasRelatedWork W2418413580 @default.
- W110291916 hasRelatedWork W2418670606 @default.
- W110291916 hasRelatedWork W2419318599 @default.
- W110291916 isParatext "false" @default.
- W110291916 isRetracted "false" @default.
- W110291916 magId "110291916" @default.
- W110291916 workType "book-chapter" @default.