FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1103374182> ?p ?o ?g. }

• W1103374182 endingPage "1094" @default.
• W1103374182 startingPage "1081" @default.
• W1103374182 abstract "The objective of this study is to examine the direct effects of low doses and high doses of ε-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in combination [ε-viniferin + vincristine] on HepG2 cell strain, as well as evaluate oxidative stress after incubation periods of 3, 6, and 24 h. Direct effect was determined right after the incubation period; however, for protective effect, antioxidant protection response was determined after the treatment for 1 h with 500 μM H2O2, which is an oxidative stressor. For this purpose, superoxide dismutase was determined for enzyme activity, and lipid hydroperoxide (LPO) and reduced glutathione concentrations were studied as indicators of oxidative stress. Results show that low [3.63 µM vincristine + 3.75 µM ε-viniferin] and high [11.25 µM vincristine + 15.8 µM ε-viniferin] doses of combination groups showed similar direct antioxidant effect on LPO levels as protective when compared to the H2O2 control group (p < 0.05). Superoxide dismutase enzyme showed a direct antioxidant effect in low and high dose combination groups. In addition, when the incubation period was increased to 24 h, a protective effect was observed in both dose groups (p < 0.05). Reduced glutathione activities showed a direct effect in the low dose combination group, and a protective effect in both the low and high doses in the 24 h. These results show that combined usage of drugs in HepG2 cell strain possesses a protective effect against exogenically produced oxidative stress conditions." @default.
• W1103374182 created "2016-06-24" @default.
• W1103374182 creator A5000106998 @default.
• W1103374182 creator A5050192187 @default.
• W1103374182 creator A5067418080 @default.
• W1103374182 creator A5088833074 @default.
• W1103374182 date "2015-08-01" @default.
• W1103374182 modified "2023-09-26" @default.
• W1103374182 title "Direct and protective effects of single or combined addition of vincristine and ε-viniferin on human HepG2 cellular oxidative stress markers in vitro" @default.
• W1103374182 cites W1121555848 @default.
• W1103374182 cites W1968986908 @default.
• W1103374182 cites W1977674781 @default.
• W1103374182 cites W1979501382 @default.
• W1103374182 cites W1984323801 @default.
• W1103374182 cites W1991690086 @default.
• W1103374182 cites W1992948298 @default.
• W1103374182 cites W1995050066 @default.
• W1103374182 cites W2001331638 @default.
• W1103374182 cites W2013704428 @default.
• W1103374182 cites W2014355861 @default.
• W1103374182 cites W2016407236 @default.
• W1103374182 cites W2020433921 @default.
• W1103374182 cites W2030718465 @default.
• W1103374182 cites W2050625990 @default.
• W1103374182 cites W2051607629 @default.
• W1103374182 cites W2051863666 @default.
• W1103374182 cites W2055120856 @default.
• W1103374182 cites W2060724306 @default.
• W1103374182 cites W2061260890 @default.
• W1103374182 cites W2063166081 @default.
• W1103374182 cites W2063854658 @default.
• W1103374182 cites W2064769568 @default.
• W1103374182 cites W2071263425 @default.
• W1103374182 cites W2071323719 @default.
• W1103374182 cites W2074618914 @default.
• W1103374182 cites W2080588989 @default.
• W1103374182 cites W2081390089 @default.
• W1103374182 cites W2082352089 @default.
• W1103374182 cites W2082465525 @default.
• W1103374182 cites W2087335973 @default.
• W1103374182 cites W2087797348 @default.
• W1103374182 cites W2090232424 @default.
• W1103374182 cites W2108300681 @default.
• W1103374182 cites W2108707108 @default.
• W1103374182 cites W2132001873 @default.
• W1103374182 cites W2135482855 @default.
• W1103374182 cites W2136239966 @default.
• W1103374182 cites W2142188924 @default.
• W1103374182 cites W2144862608 @default.
• W1103374182 cites W2146663091 @default.
• W1103374182 cites W2161585328 @default.
• W1103374182 cites W2164572791 @default.
• W1103374182 cites W2315895485 @default.
• W1103374182 cites W2377957716 @default.
• W1103374182 cites W2443471775 @default.
• W1103374182 cites W2470960012 @default.
• W1103374182 cites W9294019 @default.
• W1103374182 doi "https://doi.org/10.1007/s10616-015-9863-z" @default.
• W1103374182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4960156" @default.
• W1103374182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26228177" @default.
• W1103374182 hasPublicationYear "2015" @default.
• W1103374182 type Work @default.
• W1103374182 sameAs 1103374182 @default.
• W1103374182 citedByCount "5" @default.
• W1103374182 countsByYear W11033741822017 @default.
• W1103374182 countsByYear W11033741822021 @default.
• W1103374182 countsByYear W11033741822022 @default.
• W1103374182 countsByYear W11033741822023 @default.
• W1103374182 crossrefType "journal-article" @default.
• W1103374182 hasAuthorship W1103374182A5000106998 @default.
• W1103374182 hasAuthorship W1103374182A5050192187 @default.
• W1103374182 hasAuthorship W1103374182A5067418080 @default.
• W1103374182 hasAuthorship W1103374182A5088833074 @default.
• W1103374182 hasBestOaLocation W11033741822 @default.
• W1103374182 hasConcept C126322002 @default.
• W1103374182 hasConcept C181199279 @default.
• W1103374182 hasConcept C185592680 @default.
• W1103374182 hasConcept C25642318 @default.
• W1103374182 hasConcept C2775838275 @default.
• W1103374182 hasConcept C2776151105 @default.
• W1103374182 hasConcept C2776694085 @default.
• W1103374182 hasConcept C2776755627 @default.
• W1103374182 hasConcept C2778004101 @default.
• W1103374182 hasConcept C2779429289 @default.
• W1103374182 hasConcept C538909803 @default.
• W1103374182 hasConcept C55493867 @default.
• W1103374182 hasConcept C71924100 @default.
• W1103374182 hasConcept C86803240 @default.
• W1103374182 hasConcept C98274493 @default.
• W1103374182 hasConceptScore W1103374182C126322002 @default.
• W1103374182 hasConceptScore W1103374182C181199279 @default.
• W1103374182 hasConceptScore W1103374182C185592680 @default.
• W1103374182 hasConceptScore W1103374182C25642318 @default.
• W1103374182 hasConceptScore W1103374182C2775838275 @default.
• W1103374182 hasConceptScore W1103374182C2776151105 @default.
• W1103374182 hasConceptScore W1103374182C2776694085 @default.
• W1103374182 hasConceptScore W1103374182C2776755627 @default.
• W1103374182 hasConceptScore W1103374182C2778004101 @default.

• next