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- W1105491 abstract "Publisher Summary This chapter presents the specificity of natural cytotoxic cells. The effector suspension armed with natural antibodies possesses the capacity to react specifically with most cultured targets giving an appearance of nonselectiveness to these reactions. The effector cell itself appears to be nonselective; it is the natural antibodies to a wide spectrum of antigens that provide specificity to the reaction. It has been suggested that natural or spontaneous cell-mediated cytotoxicity (NCMC) is directed against viral antigens and, indeed, natural antibodies to various viruses have been detected. Each individual possesses a different spectrum of natural antibodies, resulting in different patterns of cytotoxicity against targets when their effector cells are reconstituted with corresponding antibodies. A more thorough investigation of natural cytotoxicity in man manifesting specific cytotoxic activity against a multiplicity of determinants will lead to a fuller understanding of host defenses and surveillance. The apparent nonselective reactivity of NCMC for cultured target cells is the sum of multiple specific reactions. A subclass of lymphocytes with Fc receptors interacts with circulating natural antibodies that confer specificity." @default.
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- W1105491 date "1979-01-01" @default.
- W1105491 modified "2023-09-24" @default.
- W1105491 title "SPECIFICITY OF NATURAL CYTOTOXIC CELLS DETERMINED BY ANTIBODY" @default.
- W1105491 doi "https://doi.org/10.1016/b978-0-12-584650-9.50016-x" @default.
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