FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W110557356> ?p ?o ?g. }

• W110557356 endingPage "1019" @default.
• W110557356 startingPage "1015" @default.
• W110557356 abstract "Elevation of either cAMP or cGMP causes smooth muscle relaxation. Whether these effects are mediated through cAMP-dependent protein kinase (cAK), cGMP-dependent protein kinase (cGK), or both is unknown. Pig coronary arteries were treated with sodium nitroprusside (SNP) or atrial natriuretic factor (ANF), relaxants which elevate cGMP, and with isoproterenol or forskolin, relaxants which elevate cAMP. Incubation of the arteries with 10 microM SNP produced a 3.3-fold increase in cGMP without altering cAMP; the cGK activity ratio (-cGMP/+cGMP) in these extracts was increased by 2.6-fold as determined by a newly developed assay, while the cAK activity ratio (-cAMP/+cAMP) was unchanged. The increase in cGK activity ratio by SNP was concentration-dependent and was nearly maximal at 30 s. Treatment of the tissue with 10 nM ANF also increased the cGK activity ratio (2.3-fold), but not that of cAK. 100 microM isoproterenol caused a 2.9-fold elevation of cAMP with no change in cGMP, but both cAK and cGK activity ratios were increased (2.3- and 1.6-fold, respectively). The increase in the cGK activity ratio could be mimicked by cAMP addition to control tissue extracts at the concentration measured in extracts of the isoproterenol-treated tissue. Forskolin (1 and 10 microM) also increased the cGK activity ratio (1.9- and 4.9-fold). The increases in cGK activity observed in extracts suggest that moderate elevation of either cGMP or cAMP causes intracellular cGK activation, thus producing relaxation of vascular smooth muscle." @default.
• W110557356 created "2016-06-24" @default.
• W110557356 creator A5012382947 @default.
• W110557356 creator A5034675601 @default.
• W110557356 creator A5036851298 @default.
• W110557356 creator A5045331047 @default.
• W110557356 date "1992-01-01" @default.
• W110557356 modified "2023-10-14" @default.
• W110557356 title "Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries." @default.
• W110557356 cites W1458204101 @default.
• W110557356 cites W1481257580 @default.
• W110557356 cites W1486377867 @default.
• W110557356 cites W1518970589 @default.
• W110557356 cites W1520611194 @default.
• W110557356 cites W1582322269 @default.
• W110557356 cites W1598689840 @default.
• W110557356 cites W1623130590 @default.
• W110557356 cites W1975827500 @default.
• W110557356 cites W2009291798 @default.
• W110557356 cites W2023117303 @default.
• W110557356 cites W2046953488 @default.
• W110557356 cites W2049301180 @default.
• W110557356 cites W2051848120 @default.
• W110557356 cites W2053197617 @default.
• W110557356 cites W2060739597 @default.
• W110557356 cites W2065265905 @default.
• W110557356 cites W2065399599 @default.
• W110557356 cites W2076376773 @default.
• W110557356 cites W2098507108 @default.
• W110557356 cites W2166979814 @default.
• W110557356 cites W2175642831 @default.
• W110557356 cites W2251920431 @default.
• W110557356 cites W2414561396 @default.
• W110557356 cites W4293247451 @default.
• W110557356 cites W49636112 @default.
• W110557356 cites W84724570 @default.
• W110557356 doi "https://doi.org/10.1016/s0021-9258(18)48388-3" @default.
• W110557356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1309758" @default.
• W110557356 hasPublicationYear "1992" @default.
• W110557356 type Work @default.
• W110557356 sameAs 110557356 @default.
• W110557356 citedByCount "252" @default.
• W110557356 countsByYear W1105573562012 @default.
• W110557356 countsByYear W1105573562013 @default.
• W110557356 countsByYear W1105573562014 @default.
• W110557356 countsByYear W1105573562015 @default.
• W110557356 countsByYear W1105573562019 @default.
• W110557356 countsByYear W1105573562020 @default.
• W110557356 countsByYear W1105573562021 @default.
• W110557356 countsByYear W1105573562023 @default.
• W110557356 crossrefType "journal-article" @default.
• W110557356 hasAuthorship W110557356A5012382947 @default.
• W110557356 hasAuthorship W110557356A5034675601 @default.
• W110557356 hasAuthorship W110557356A5036851298 @default.
• W110557356 hasAuthorship W110557356A5045331047 @default.
• W110557356 hasBestOaLocation W1105573561 @default.
• W110557356 hasConcept C126322002 @default.
• W110557356 hasConcept C134018914 @default.
• W110557356 hasConcept C164705383 @default.
• W110557356 hasConcept C184235292 @default.
• W110557356 hasConcept C185592680 @default.
• W110557356 hasConcept C199217515 @default.
• W110557356 hasConcept C2776820930 @default.
• W110557356 hasConcept C2778742706 @default.
• W110557356 hasConcept C71924100 @default.
• W110557356 hasConcept C86803240 @default.
• W110557356 hasConcept C90934575 @default.
• W110557356 hasConcept C95444343 @default.
• W110557356 hasConcept C97029542 @default.
• W110557356 hasConceptScore W110557356C126322002 @default.
• W110557356 hasConceptScore W110557356C134018914 @default.
• W110557356 hasConceptScore W110557356C164705383 @default.
• W110557356 hasConceptScore W110557356C184235292 @default.
• W110557356 hasConceptScore W110557356C185592680 @default.
• W110557356 hasConceptScore W110557356C199217515 @default.
• W110557356 hasConceptScore W110557356C2776820930 @default.
• W110557356 hasConceptScore W110557356C2778742706 @default.
• W110557356 hasConceptScore W110557356C71924100 @default.
• W110557356 hasConceptScore W110557356C86803240 @default.
• W110557356 hasConceptScore W110557356C90934575 @default.
• W110557356 hasConceptScore W110557356C95444343 @default.
• W110557356 hasConceptScore W110557356C97029542 @default.
• W110557356 hasIssue "2" @default.
• W110557356 hasLocation W1105573561 @default.
• W110557356 hasOpenAccess W110557356 @default.
• W110557356 hasPrimaryLocation W1105573561 @default.
• W110557356 hasRelatedWork W1972855197 @default.
• W110557356 hasRelatedWork W1998355348 @default.
• W110557356 hasRelatedWork W2039759118 @default.
• W110557356 hasRelatedWork W2074628308 @default.
• W110557356 hasRelatedWork W2137346714 @default.
• W110557356 hasRelatedWork W2166847096 @default.
• W110557356 hasRelatedWork W2240768837 @default.
• W110557356 hasRelatedWork W2346883865 @default.
• W110557356 hasRelatedWork W3215846639 @default.
• W110557356 hasRelatedWork W4232263000 @default.
• W110557356 hasVolume "267" @default.
• W110557356 isParatext "false" @default.

• next