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- W110602242 abstract "This chapter discusses the effect of parachlorophenylalanine (PCPA) on sleep in the rat. It discusses some implications for the serotonin (5-HT)-sleep hypothesis. The chapter describes a series of PCPA studies, with male Sprague–Dawley albino rats. The conditions of these experiments were reviewed to evaluate the possible contribution of factors such as age of rats, season, ambient noise levels, and interscorer reliabilities. None of these factors appeared to account for the diversity. The effectiveness of the drug in lowering brain 5-HT did not seem to be a factor. Assays showed similar depletions of about 85% to 90% in different experiments with different modes of drug administration. If the crude hypothesis is supported, it admits of the possibility of a more refined action. When the crude hypothesis is not supported, it does not deny the possibility of more refined action. The hypothesis of refined action is often invoked to explain the failure of crude action." @default.
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- W110602242 date "1973-01-01" @default.
- W110602242 modified "2023-10-16" @default.
- W110602242 title "THE EFFECT OF PARACHLOROPHENYLALANINE ON SLEEP IN THE RAT: SOME IMPLICATIONS FOR THE SEROTONIN-SLEEP HYPOTHESIS" @default.
- W110602242 doi "https://doi.org/10.1016/b978-0-12-078150-8.50053-0" @default.
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