FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W110608082> ?p ?o ?g. }

• W110608082 abstract "OF THESIS INVESTIGATION OF THE TOXICITY AND EFFLUX OF POLYCHLORINATED BIPHENYLS AND HYDROXYLATED POLYCHLORINATED BIPHENYLS IN ESCHERICHIA COLI Polychlorinated biphenyls (PCBs) are persistent organic pollutants. Due to their properties, PCBs accumulate in the food-chain and post a threat to the health of human beings and wildlife. Hydroxylated PCBs (OH-PCBs) are oxidative metabolites of PCBs and are more hydrophilic than their parent PCBs. One of the best approaches to break down these contaminants is through bioremediation, which is an environmental friendly process that uses microorganisms to restore natural environment. Towards this goal, we have investigated the toxicity and accumulation of PCBs and OH-PCBs in a Gram-negative bacterium, Escherichia coli. We have also determined the role played by a primary multidrug efflux transporter AcrB on the accumulation of PCBs and OH-PCBs in bacterial cell. We found that none of the PCBs tested was toxic to E. coli, while different OH-PCBs have different levels of toxicity; the acrB knockout strain accumulated significantly more PCBs and OH-PCBs than the wild-type strain, suggesting that these compounds are substrates of the efflux pump; higher cytoplasmic concentrations of OH-PCBs were also observed in the acrB knockout strain using the biosensors. Based on these observations, we conclude that both PCBs and OH-PCBs are substrates of protein AcrB. Therefore the efflux activities of multidrug resistant pumps in Gram-negative bacteria should be considered while designing bioremediation approaches." @default.
• W110608082 created "2016-06-24" @default.
• W110608082 creator A5008439108 @default.
• W110608082 date "2011-01-01" @default.
• W110608082 modified "2023-09-27" @default.
• W110608082 title "INVESTIGATION OF THE TOXICITY AND EFFLUX OF POLYCHLORINATED BIPHENYLS AND HYDROXYLATED POLYCHLORINATED BIPHENYLS IN ESCHERICHIA COLI" @default.
• W110608082 cites W156796704 @default.
• W110608082 cites W1864427654 @default.
• W110608082 cites W1964296117 @default.
• W110608082 cites W1969433141 @default.
• W110608082 cites W1974717319 @default.
• W110608082 cites W1987377413 @default.
• W110608082 cites W1994795625 @default.
• W110608082 cites W1995335528 @default.
• W110608082 cites W1997623341 @default.
• W110608082 cites W1999099977 @default.
• W110608082 cites W2005997880 @default.
• W110608082 cites W2016310470 @default.
• W110608082 cites W2016800998 @default.
• W110608082 cites W2020723831 @default.
• W110608082 cites W2030511562 @default.
• W110608082 cites W2031010160 @default.
• W110608082 cites W2032303539 @default.
• W110608082 cites W2035120653 @default.
• W110608082 cites W2040387795 @default.
• W110608082 cites W2042669181 @default.
• W110608082 cites W2048077194 @default.
• W110608082 cites W2048685873 @default.
• W110608082 cites W2058952776 @default.
• W110608082 cites W2062743944 @default.
• W110608082 cites W2075755324 @default.
• W110608082 cites W2076907968 @default.
• W110608082 cites W2077534797 @default.
• W110608082 cites W2090436685 @default.
• W110608082 cites W2094451152 @default.
• W110608082 cites W2096172849 @default.
• W110608082 cites W2097640136 @default.
• W110608082 cites W2098583921 @default.
• W110608082 cites W2102852978 @default.
• W110608082 cites W2107250776 @default.
• W110608082 cites W2120111519 @default.
• W110608082 cites W2136723682 @default.
• W110608082 cites W2139414608 @default.
• W110608082 cites W2149972393 @default.
• W110608082 cites W2150710716 @default.
• W110608082 cites W2152780287 @default.
• W110608082 cites W2153601116 @default.
• W110608082 cites W2417412750 @default.
• W110608082 hasPublicationYear "2011" @default.
• W110608082 type Work @default.
• W110608082 sameAs 110608082 @default.
• W110608082 citedByCount "1" @default.
• W110608082 countsByYear W1106080822013 @default.
• W110608082 crossrefType "journal-article" @default.
• W110608082 hasAuthorship W110608082A5008439108 @default.
• W110608082 hasConcept C104317684 @default.
• W110608082 hasConcept C107872376 @default.
• W110608082 hasConcept C112570922 @default.
• W110608082 hasConcept C175605896 @default.
• W110608082 hasConcept C178790620 @default.
• W110608082 hasConcept C185592680 @default.
• W110608082 hasConcept C18903297 @default.
• W110608082 hasConcept C200082930 @default.
• W110608082 hasConcept C2124996 @default.
• W110608082 hasConcept C29730261 @default.
• W110608082 hasConcept C523546767 @default.
• W110608082 hasConcept C54355233 @default.
• W110608082 hasConcept C547475151 @default.
• W110608082 hasConcept C55493867 @default.
• W110608082 hasConcept C82685317 @default.
• W110608082 hasConcept C86803240 @default.
• W110608082 hasConceptScore W110608082C104317684 @default.
• W110608082 hasConceptScore W110608082C107872376 @default.
• W110608082 hasConceptScore W110608082C112570922 @default.
• W110608082 hasConceptScore W110608082C175605896 @default.
• W110608082 hasConceptScore W110608082C178790620 @default.
• W110608082 hasConceptScore W110608082C185592680 @default.
• W110608082 hasConceptScore W110608082C18903297 @default.
• W110608082 hasConceptScore W110608082C200082930 @default.
• W110608082 hasConceptScore W110608082C2124996 @default.
• W110608082 hasConceptScore W110608082C29730261 @default.
• W110608082 hasConceptScore W110608082C523546767 @default.
• W110608082 hasConceptScore W110608082C54355233 @default.
• W110608082 hasConceptScore W110608082C547475151 @default.
• W110608082 hasConceptScore W110608082C55493867 @default.
• W110608082 hasConceptScore W110608082C82685317 @default.
• W110608082 hasConceptScore W110608082C86803240 @default.
• W110608082 hasLocation W1106080821 @default.
• W110608082 hasOpenAccess W110608082 @default.
• W110608082 hasPrimaryLocation W1106080821 @default.
• W110608082 hasRelatedWork W1966614664 @default.
• W110608082 hasRelatedWork W1989713598 @default.
• W110608082 hasRelatedWork W2003752565 @default.
• W110608082 hasRelatedWork W2092260527 @default.
• W110608082 hasRelatedWork W2092716702 @default.
• W110608082 hasRelatedWork W2109677699 @default.
• W110608082 hasRelatedWork W2147434352 @default.
• W110608082 hasRelatedWork W2322178865 @default.
• W110608082 hasRelatedWork W2419020621 @default.
• W110608082 hasRelatedWork W2618490431 @default.

• next