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- W110613151 abstract "Abstract MICA (major histocompatibility complex class I chain-related genes A) is known to be associated with susceptibility to various autoimmune diseases. Recent studies have also demonstrated that MICA*A5.1, one allele of MICA, contributed to the resistance of microorganism infection. The aim of this study was to investigate the association between MICA*A5.1 allele and ankylosing spondylitis (AS). A total of 144 AS patients selected from south China and 110 ethnically matched unrelated healthy controls were typed for MICA*A5.1 polymorphism in addition to HLA-B27 typing by polymerase chain reaction using sequence-specific primers. Statistical analysis revealed: (1) a significantly higher frequency of HLA-B27 in the patient group (96.5%) than in the control group (8.2%) (P < 0.0001); (2) the distribution of MICA*A5.1 genotype was significantly different between the patients and controls (P = 0.029), the frequency of MICA*A5.1 homozygote was significantly decreased in the patient group (2.1%) as compared with the controls (8.9%) (P = 0.023); (3) the association between MICA*A5.1 genotype and AS is not independent of HLA-B27 status (P = 0.94). These results suggest that MICA*A5.1 allele may play a potential role in the protection against AS." @default.
- W110613151 created "2016-06-24" @default.
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- W110613151 date "2009-04-01" @default.
- W110613151 modified "2023-09-26" @default.
- W110613151 title "Investigation of MICA*A5.1 Allele in Ankylosing Spondylitis (49.23)" @default.
- W110613151 doi "https://doi.org/10.4049/jimmunol.182.supp.49.23" @default.
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