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- W110685794 abstract "In 1981 when the Medical Research Council set up their trial of the treatment of hypertension in older adults, the efficacy, safety and practicability of drug treatment for hypertension in older people was largely unknown. The existing controlled trial literature on the primary or secondary prevention of cardiovascular disease, through treatment of hypertension, was inadequate for two principal reasons. First, it had reported on only a small number of subjects and events from adults aged 60 or older at entry [1–5]. For example, the trial by Sprackling [1] involved only 60 subjects in each of the treatment and control groups, and the trial reported by Carter [2] had only 49 subjects randomised to the treatment and 48 to the control group. The second problem with the published literature in 1981 was that the larger hypertension trials, if they had considered patients aged over 60 at all, had reported these results as subgroup analyses which lacked statistical power and prompted questions rather than answered them [6–10]." @default.
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- W110685794 date "1994-01-01" @default.
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- W110685794 title "Medical Research Council trial of treatment of hypertension in older adults: main results and treatment implications" @default.
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- W110685794 doi "https://doi.org/10.1007/978-94-017-1820-2_7" @default.
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