FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W110707003> ?p ?o ?g. }

• W110707003 abstract "Kimutattuk, hogy elektrofil metil gyokoket tartalmazo biomolekulakbol (pl. foszfatidilkolin -PC) metan kepződhet reduktiv korulmenyek kozott es bizonyitottuk, hogy a reakcio in vivo korulmenyek kozott is lejatszodhat: igazoltuk a metangaz megjeleneset elő mitokondriumokat tartalmazo reakciokozegben hipoxia alatt. Megvizsgaltuk a gasztrointesztinalis nyalkahartya reakciojat es a PC kezeles hatasait reduktiv/oxidativ stressz allapotokban, meghataroztuk a helyi vagy altalanos oxigenhianyt kiserő intramuralis mikrokeringesi reakciokat szamos allatkiserletes modellben (verzes, szepszis, a nitrogen monoxid szintezis gatlasa, az arterias keringes elzarodasa) in vivo korulmenyek kozott. Uj modszert dolgoztunk ki a mikrokeringesi zavarok objektiv leirasara, mellyel sikerult a terben es időben egyarant valtozo perfuzios mintazatok osszehasonlitasa; s igy az egyes kezelesek hatekonysagat objektivan megitelhettuk. Jellemeztuk a nyelőcső, a gyomor es a vekonybel nyalkahartya intramuralis mikrokeringeset elettani es koros korulmenyek kozott is, es kimutattuk, hogy a PC kezeles rendkivul hatekonyan csokkenti a mucosa mikrokeringesi zavarat, a helyi gyulladasos reakciot es jelentősen mersekli a szovetek strukturalis karosodasat is. Eredmenyeink bizonyitjak a PC molekula jelentős gyulladascsokkentő hatasat; s ennek a felismeresnek klinikai-terapias konzekvenciai lehetnek az oxido-reduktiv stressz es a kovetkezmenyes gyulladasos reakciok befolyasolasa teren. | Our first goal was to explore the mechanistic details of an intracellular system which may operate by capture of electrons and the consequent irreversible evolution of methane gas. Possible intracellular candidates for this reaction were phosphatidylcholine (PC) and some other compounds with electrophylic methyl moieties. Supporting this finding, the formation of methane in isolated rat liver mitochondria has been observed. Our second goal was to develop strategies to preserve the structural and functional integrity of the gastrointestinal tract in clinical conditions with oxido-reductive stress. The microcirculation was monitored by means of intravital videomicroscopy in several in vivo animal models. We applied a novel mathematical approach to quantify the time-wise and spatial heterogeneity of tissue microcirculation during systemic (hemorrhagic shock, endotoxemia, and nitric oxide synthesis inhibition) and local (ischemia-reperfusion) circulatory disorders. We observed and characterized distinct intramural microcirculatory changes in the oesophagus, stomach and small intestine in normal and stress conditions. The results show that PC treatment regimens effectively modulate the outcome of an oxido-reductive stress-induced inflammatory reaction." @default.
• W110707003 created "2016-06-24" @default.
• W110707003 creator A5006860584 @default.
• W110707003 creator A5018021794 @default.
• W110707003 creator A5049775704 @default.
• W110707003 creator A5050664604 @default.
• W110707003 creator A5075193948 @default.
• W110707003 creator A5079846890 @default.
• W110707003 date "2006-01-01" @default.
• W110707003 modified "2023-10-08" @default.
• W110707003 title "A gastrointestinalis nyálkahártya mikrokeringési változásai oxido-redukciós stressz állapotokban = Gastrointestinal microcirculatory changes during oxido-reductive stress conditions" @default.
• W110707003 hasPublicationYear "2006" @default.
• W110707003 type Work @default.
• W110707003 sameAs 110707003 @default.
• W110707003 citedByCount "0" @default.
• W110707003 crossrefType "journal-article" @default.
• W110707003 hasAuthorship W110707003A5006860584 @default.
• W110707003 hasAuthorship W110707003A5018021794 @default.
• W110707003 hasAuthorship W110707003A5049775704 @default.
• W110707003 hasAuthorship W110707003A5050664604 @default.
• W110707003 hasAuthorship W110707003A5075193948 @default.
• W110707003 hasAuthorship W110707003A5079846890 @default.
• W110707003 hasConcept C126322002 @default.
• W110707003 hasConcept C185592680 @default.
• W110707003 hasConcept C55493867 @default.
• W110707003 hasConcept C71924100 @default.
• W110707003 hasConcept C79879829 @default.
• W110707003 hasConceptScore W110707003C126322002 @default.
• W110707003 hasConceptScore W110707003C185592680 @default.
• W110707003 hasConceptScore W110707003C55493867 @default.
• W110707003 hasConceptScore W110707003C71924100 @default.
• W110707003 hasConceptScore W110707003C79879829 @default.
• W110707003 hasLocation W1107070031 @default.
• W110707003 hasOpenAccess W110707003 @default.
• W110707003 hasPrimaryLocation W1107070031 @default.
• W110707003 hasRelatedWork W1000098286 @default.
• W110707003 hasRelatedWork W1000795788 @default.
• W110707003 hasRelatedWork W1016295290 @default.
• W110707003 hasRelatedWork W142667690 @default.
• W110707003 hasRelatedWork W16713901 @default.
• W110707003 hasRelatedWork W169750327 @default.
• W110707003 hasRelatedWork W173553793 @default.
• W110707003 hasRelatedWork W2592076638 @default.
• W110707003 hasRelatedWork W357600755 @default.
• W110707003 hasRelatedWork W418836812 @default.
• W110707003 hasRelatedWork W606540316 @default.
• W110707003 hasRelatedWork W80496504 @default.
• W110707003 hasRelatedWork W881148 @default.
• W110707003 hasRelatedWork W942135319 @default.
• W110707003 hasRelatedWork W955811329 @default.
• W110707003 hasRelatedWork W958921717 @default.
• W110707003 hasRelatedWork W986809079 @default.
• W110707003 hasRelatedWork W1019300489 @default.
• W110707003 hasRelatedWork W1769444937 @default.
• W110707003 hasRelatedWork W994214728 @default.
• W110707003 isParatext "false" @default.
• W110707003 isRetracted "false" @default.
• W110707003 magId "110707003" @default.
• W110707003 workType "article" @default.