FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W11075894> ?p ?o ?g. }

• W11075894 abstract "Basic fibroblast growth factor (FGF) induced a rapid increase in tyrosine phosphorylation of a 57-kDa cytoplasmic protein with functional myelin basic protein kinase activity and antigenic properties common to mitogen-activated kinases or extracellular signal-regulated kinases. Basic and acidic FGFs and the diacylglycerol diolein used the same signal transduction pathway to activate pp57. These FGFs, like diolein (Lee, H., Ghose-Dastidar, J., Winawer, S., and Friedman, E. (1993) J. Biol. Chem., 268, 5255-5263), increased the cellular concentration of long-chain diacylglycerols within the same short time period as they increased pp57 tyrosine phosphorylation. Both FGF and diolein increased phosphorylation of pp57 on the same V8 protease-generated fragments, suggesting a common pathway for the phosphorylation of pp57. FGF-induced signal transduction through pp57 mitogen-activated kinase led to cell growth in two undifferentiated colon carcinoma cell lines. In contrast, basic FGF neither increased tyrosine phosphorylation of pp57 nor increased cell growth in two colon goblet cell differentiated lines derived from the same parental line as the undifferentiated cells. Both goblet cell lines exhibited levels of protein-tyrosine kinase activity about one-fifth that of the undifferentiated lines. The decrease in tyrosine kinase activity was not due to down-regulation of FGF receptors or their tyrosine kinase activities. c-src kinase-specific activity was decreased 4-5-fold in both goblet cell lines, suggesting a role for c-src in pp57-mediated signal transduction." @default.
• W11075894 created "2016-06-24" @default.
• W11075894 creator A5020882945 @default.
• W11075894 creator A5029800309 @default.
• W11075894 creator A5041915991 @default.
• W11075894 creator A5075257352 @default.
• W11075894 date "1993-04-01" @default.
• W11075894 modified "2023-09-29" @default.
• W11075894 title "Signal transduction through extracellular signal-regulated kinase-like pp57 blocked in differentiated colon carcinoma cells having low levels of c-src kinase." @default.
• W11075894 cites W139618738 @default.
• W11075894 cites W1511031451 @default.
• W11075894 cites W1514636046 @default.
• W11075894 cites W1552785074 @default.
• W11075894 cites W1555409791 @default.
• W11075894 cites W1576331029 @default.
• W11075894 cites W165372149 @default.
• W11075894 cites W1660489924 @default.
• W11075894 cites W1892096673 @default.
• W11075894 cites W1970038583 @default.
• W11075894 cites W1971334343 @default.
• W11075894 cites W1974873948 @default.
• W11075894 cites W1975972551 @default.
• W11075894 cites W1977472414 @default.
• W11075894 cites W1978798502 @default.
• W11075894 cites W1985399284 @default.
• W11075894 cites W1997218197 @default.
• W11075894 cites W2002623358 @default.
• W11075894 cites W2003628336 @default.
• W11075894 cites W2007497409 @default.
• W11075894 cites W2007510904 @default.
• W11075894 cites W2009338295 @default.
• W11075894 cites W2017724386 @default.
• W11075894 cites W2020537787 @default.
• W11075894 cites W2036895735 @default.
• W11075894 cites W2046163031 @default.
• W11075894 cites W2049744804 @default.
• W11075894 cites W2051958366 @default.
• W11075894 cites W2053286013 @default.
• W11075894 cites W2054582733 @default.
• W11075894 cites W2069132844 @default.
• W11075894 cites W2074192925 @default.
• W11075894 cites W2075699262 @default.
• W11075894 cites W2076567606 @default.
• W11075894 cites W2077339073 @default.
• W11075894 cites W2082460645 @default.
• W11075894 cites W2089686093 @default.
• W11075894 cites W2100837269 @default.
• W11075894 cites W2164358316 @default.
• W11075894 cites W2312445582 @default.
• W11075894 doi "https://doi.org/10.1016/s0021-9258(18)53079-9" @default.
• W11075894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7681838" @default.
• W11075894 hasPublicationYear "1993" @default.
• W11075894 type Work @default.
• W11075894 sameAs 11075894 @default.
• W11075894 citedByCount "16" @default.
• W11075894 countsByYear W110758942012 @default.
• W11075894 countsByYear W110758942016 @default.
• W11075894 crossrefType "journal-article" @default.
• W11075894 hasAuthorship W11075894A5020882945 @default.
• W11075894 hasAuthorship W11075894A5029800309 @default.
• W11075894 hasAuthorship W11075894A5041915991 @default.
• W11075894 hasAuthorship W11075894A5075257352 @default.
• W11075894 hasBestOaLocation W110758941 @default.
• W11075894 hasConcept C101544691 @default.
• W11075894 hasConcept C108636557 @default.
• W11075894 hasConcept C153911025 @default.
• W11075894 hasConcept C170493617 @default.
• W11075894 hasConcept C180361614 @default.
• W11075894 hasConcept C195794163 @default.
• W11075894 hasConcept C2775960820 @default.
• W11075894 hasConcept C2777553839 @default.
• W11075894 hasConcept C42362537 @default.
• W11075894 hasConcept C55493867 @default.
• W11075894 hasConcept C62478195 @default.
• W11075894 hasConcept C86803240 @default.
• W11075894 hasConcept C90934575 @default.
• W11075894 hasConcept C95444343 @default.
• W11075894 hasConceptScore W11075894C101544691 @default.
• W11075894 hasConceptScore W11075894C108636557 @default.
• W11075894 hasConceptScore W11075894C153911025 @default.
• W11075894 hasConceptScore W11075894C170493617 @default.
• W11075894 hasConceptScore W11075894C180361614 @default.
• W11075894 hasConceptScore W11075894C195794163 @default.
• W11075894 hasConceptScore W11075894C2775960820 @default.
• W11075894 hasConceptScore W11075894C2777553839 @default.
• W11075894 hasConceptScore W11075894C42362537 @default.
• W11075894 hasConceptScore W11075894C55493867 @default.
• W11075894 hasConceptScore W11075894C62478195 @default.
• W11075894 hasConceptScore W11075894C86803240 @default.
• W11075894 hasConceptScore W11075894C90934575 @default.
• W11075894 hasConceptScore W11075894C95444343 @default.
• W11075894 hasLocation W110758941 @default.
• W11075894 hasOpenAccess W11075894 @default.
• W11075894 hasPrimaryLocation W110758941 @default.
• W11075894 hasRelatedWork W1524268866 @default.
• W11075894 hasRelatedWork W1531194664 @default.
• W11075894 hasRelatedWork W1552281474 @default.
• W11075894 hasRelatedWork W1552785074 @default.
• W11075894 hasRelatedWork W1566442216 @default.
• W11075894 hasRelatedWork W1774418672 @default.

• next