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- W110851915 abstract "Cisplatin (cis-dichlorodiammineplatinum II) is the first member of a new class of potent anticancer drugs, the metal coordination complexes, to enter general use in cancer chemotherapy. The drug has been proved to be effective alone or in combination for the treatment of a wide variety of solid cancers in man. Evidence suggests that it is curative for testicular cancers and ovarian cancers. It is also palliative in the treatment of cancers of the head and neck, bladder, prostate, lung, and cervix and in some pediatric cancers. The major toxic side effects of the drug are damage to the kidney, nausea, and vomiting. The hydration of the patient, with or without concomitant diuretics, ameliorates the kidney toxicity so well that in some clinical reports, it is no longer considered to be the dose-limiting side effect. The nausea and vomiting due to this drug are extreme, ubiquitous, and long lasting. Evidence has been reported indicating that nonstandard drugs such as marijuana, metaclopromide, and droperidol are effective in reducing the nausea and vomiting to an acceptable level." @default.
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- W110851915 title "CISPLATIN: ITS HISTORY AND POSSIBLE MECHANISMS OF ACTION" @default.
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- W110851915 doi "https://doi.org/10.1016/b978-0-12-565050-2.50006-1" @default.
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