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- W110858687 abstract "In this paper we study the problem of designing experiments for nonlinear regression models in pharmacokinetics. In particular, we consider an extension of the popular Michaelis-Menten model (MMM) with the addition of a linear term. D-optimal designs supported at 3 points with equal weights are calculated for the MMM extension using the general equivalence theorem. This model is a special case of partially nonlinear regression. We obtain c-, D-optimal designs for estimating the three parameters of the model. Next we calculate compound designs. Some numerical examples are provided with efficiencies for estimating each of the parameters." @default.
- W110858687 created "2016-06-24" @default.
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- W110858687 date "2004-01-01" @default.
- W110858687 modified "2023-10-18" @default.
- W110858687 title "Locally Optimal Designs for an Extension of the Michaelis-Menten Model" @default.
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- W110858687 doi "https://doi.org/10.1007/978-3-7908-2693-7_19" @default.
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